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职业迁徙
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We investigate how cell death and other cellular processes affects the local tissue environment, and in particular how necrosis can induce sterile inflammation. We have a special interest in atherosclerotic plaques, which are characterized by chronic inflammation and an accumulation of apoptotic and necrotic cells. Much of our work focuses on the activation and control of the apical inflammatory cytokine IL-1. IL-1α acts as a powerful danger signal when released from dead cells, and also controls the senescence-associated secretory phenotype, while IL-1β is activated and released in large amounts by the inflammasomes. Our recent work shows that multiple systems are needed to keep basal IL-1 activity under control and that small aberrations in IL-1 signalling can lead to immune dysfunction under the steady state.
We investigate how cell death and other cellular processes affects the local tissue environment, and in particular how necrosis can induce sterile inflammation. We have a special interest in atherosclerotic plaques, which are characterized by chronic inflammation and an accumulation of apoptotic and necrotic cells. Much of our work focuses on the activation and control of the apical inflammatory cytokine IL-1. IL-1α acts as a powerful danger signal when released from dead cells, and also controls the senescence-associated secretory phenotype, while IL-1β is activated and released in large amounts by the inflammasomes. Our recent work shows that multiple systems are needed to keep basal IL-1 activity under control and that small aberrations in IL-1 signalling can lead to immune dysfunction under the steady state.
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论文共 54 篇作者统计合作学者相似作者
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Laura C. Burzynski, Alejandra Morales-Maldonado,Amanda Rodgers,Lauren A. Kitt,Melanie Humphry,Nichola Figg,Martin R. Bennett,Murray C. H. Clarke
CARDIOVASCULAR RESEARCHno. 1 (2024): 121-121
Nature Cardiovascular Researchno. 1 (2024): 23-25
Laura C. Burzynski, Alejandra Morales-Maldonado, Amanda Rodgers,Lauren A. Kitt,Melanie Humphry,Nichola Figg,Martin R. Bennett,Murray C. H. Clarke
Cardiovascular researchno. 12 (2023): 2179-2189
Atherosclerosis (2023): 117308-117308
Marta Baldrighi, Christian Doreth,Yang Li,Xiaohui Zhao, Emily Warner, Hannah Chenoweth,Kamal Kishore,Yagnesh Umrania, David-Paul Minde, Sarah Thome,Xian Yu,Yuning Lu,
JOURNAL OF CLINICAL INVESTIGATIONno. 21 (2023)
FRONTIERS IN IMMUNOLOGY (2020): 613170-613170
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