​Dr. Brown's research laboratory focuses on elucidating the epigenetic factors underlying the action of steroid hormones. This work has important implications both for normal physiology and for the treatment of hormone-dependent malignancies including breast and prostate cancer. He is recognized for three seminal discoveries. His lab helped open the steroid receptor co-regulator field, illuminated the dynamic nature of receptor and coregulator interactions with the genome and elucidated the importance of epigenetically determined distant cis-regulatory steroid receptor binding sites. His contributions have uniquely reformulated the understanding of steroid hormone action in normal physiology and in hormone-dependent cancer.