基本信息
浏览量:17
职业迁徙
个人简介
My first work in cancer research addressed the role of microsatellite instability in gastric cancer, which we found to be associated with prognosis. Next, I embarked in a doctoral project to characterize the SS18 (first designated SYT) and SSX family proteins, which were earlier identified as fusion partners in synovial sarcoma. We identified peptide sequences associated with their nuclear localization, found interacting partners, and characterized SSX protein expression as a tumor antigens in melanoma. Next, I turned my focus to the mechanisms of T-cell leukemia driven by the ETV6-JAK2 fusion. We identified a microenvironmental pro-leukemogenic role for NF-kappaB and found that the T-cell receptor (TCR) and pre-TCR impact on T-cell leukemia. These research topics have been the center of my research group’s main activities. We have found that thymic microenviromental cells and proteins, such as the lymphotoxin-beta receptor, favor T-cell leukemia development in the thymus. We have found that stimulation of TCR signaling in leukemic T cells leads to apoptosis and leukemia suppression, but are investigating whether weak TCR stimulation could have pro-leukemogenic function by inducing expression of survival or migration proteins. Our long-term goal is to understand what are the molecular determinants involved in T-cell leukemogenesis, potentially leading to novel therapeutic approaches.
研究兴趣
论文共 17 篇作者统计合作学者相似作者
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Amelie Trinquand,Nuno R. dos Santos,Christine Tran Quang, Francesca Rocchetti,Benedetta Zaniboni,Mohamed Belhocine, Cindy Da Costa de Jesus,Ludovic Lhermitte,Melania Tesio,Michael Dussiot,Francois-Loic Cosset,Els Verhoeyen,Francoise Pflumio,Norbert Ifrah,Herve Dombret,Salvatore Spicuglia,Lucienne Chatenoud,David-Alexandre Gross,Olivier Hermine,Elizabeth Macintyre,Jacques Ghysdael,Vahid Asnafi
Wiley Encyclopedia of Molecular Medicine (2002)
Wiley Encyclopedia of Molecular Medicine (2002)
Wiley Encyclopedia of Molecular Medicine (2002)
Oncogeneno. 25 (2001): 3281-3289
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作者统计
#Papers: 17
#Citation: 624
H-Index: 7
G-Index: 7
Sociability: 4
Diversity: 2
Activity: 0
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