Nam Doo Kim

Drug Design Team, Equispharm Inc., 864-1, Gyeonggi, Republic of Korea

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Papers70 papers

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The first small molecules capable of strongly suppressing proliferation of cancer cells harboring BRAF class I/II/III mutations

Seung-Hye Choi,Injae Shin,Namdoo Kim, Yunju Nam,Taebo Sim

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, no. 2 (2020): 315-320

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Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14

Fleur M Ferguson, Zainab M Doctor,Scott B Ficarro,Jarrod A Marto,Nam Doo Kim,Taebo Sim,Nathanael S Gray

Bioorganic & Medicinal Chemistry Letters, no. 15 (2019): 1985-1993

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Discovery of orally available and potent MPS1(TTK) kinase inhibitors for anti-cancer drugs

Younho Lee,Juhee Kang, Sein Kang, Hyunkyung Kim, Kyung-ah Seo, Jieun Choi, Jaeyoung Ahn,Jung Beom Son,Nam Doo Kim

CANCER RESEARCH, no. SUP13 (2019)

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Discovery of Covalent CDK14 Inhibitors with Pan-TAIRE Family Specificity

Fleur M Ferguson, Zainab M Doctor,Scott B Ficarro, Christopher M Browne,Jarrod A Marto,Jared L Johnson, Tomer M Yaron,Lewis C Cantley,Nam Doo Kim,Taebo Sim,Matthew J Berberich,Marian Kalocsay

Cell Chemical Biology, no. 6 (2019): 804-817.e12

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Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome

Suman Rao,Deepak Gurbani, Guangyan Du,Robert A Everley, Christopher M Browne,Apirat Chaikuad,Li Tan, Martin Schröder, Sudershan Gondi,Scott B Ficarro,Taebo Sim,Nam Doo Kim

Cell Chemical Biology, no. 6 (2019): 818-829.e9

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Abstract B002: Discovery of selective and potent EGFR kinase inhibitors for exon20 insertion mutations

Sunghwan Kim, Younho Lee, Hwan Kim, Juhee Kang, Jiyoon Seok, Kyung-Ah Seo, Jaeyoung Ahn, Hee-Bum Kang, Sun-Hwa Lee,Jung Beom Son,Hwan Geun Choi,Nam Doo Kim

MOLECULAR CANCER THERAPEUTICS, no. SUP12 (2019)

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Identification of a unique resorcylic acid lactone derivative that targets both lymphangiogenesis and angiogenesis

Youngsun Han, Sandip Sengupta,Byung Joo Lee, Hanna Cho, Jiknyeo Kim,Hwan Geun Choi, Uttam Dash,Jin Hyoung Kim,Nam Doo Kim,Jeong Hun Kim,Taebo Sim

JOURNAL OF MEDICINAL CHEMISTRY, no. 20 (2019): 9141-9160

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Identification of novel resorcinol amide derivatives as potent and specific pyruvate dehydrogenase kinase (PDHK) inhibitors

Hanna Cho, Injae Shin, Kyungseon Cho,Hojong Yoon,Eun Kyung Yoo, Mi-Jin Kim,Sungmi Park,In-Kyu Lee,Nam Doo Kim,Taebo Sim

JOURNAL OF MEDICINAL CHEMISTRY, no. 18 (2019): 8461-8479

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Novel therapeutic agents for RET-driven cancers, which is highly potent and selective inhibitor to RET kinase

Hua Li, SeoHyun Jo, Woomi Do, Hyunkyung Kim, Hwan Kim, Kyung-ah Seo, Ji-hoon Oh, Jieun Choi, Jaeyoung Ahn, Jung Beom Son,Nam Doo Kim

CANCER RESEARCH, no. SUP13 (2019)

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Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5

Udayakumar Karunakaran, Suma Elumalai,Jun Sung Moon,Jae Han Jeon,Nam Doo Kim,Keun Gyu Park,Kyu Chang Won, Jaechan Leem, In Kyu Lee

DIABETES & METABOLISM JOURNAL, no. 2 (2019): 192-205

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First SAR study for overriding NRAS mutant driven acute myeloid leukemia

Hanna Cho, Injae Shin, Eunhye Ju, Seunghye Choi,Wooyoung Hur, Haelee Kim, Eunmi Hong,Nam Doo Kim,Hwan Geun Choi,Nathanael S Gray,Taebo Sim

JOURNAL OF MEDICINAL CHEMISTRY, no. 18 (2018): 8353-8373

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Structural and atropisomeric factors governing the selectivity of pyrimido-benzodiazipinones as inhibitors of kinases and bromodomains

Jinhua Wang,Tatiana Erazo,Fleur M Ferguson,Dennis L Buckley, Nestor Gomez, Pau Muñoz-Guardiola, Nora Diéguez-Martínez,Xianming Deng, Mingfeng Hao, Walter Massefski,Oleg Fedorov, Nana Kwaku Offei-Addo

ACS chemical biology, no. 9 (2018): 2438-2448

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Discovery of a novel potent peptide agonist to adiponectin receptor 1

Sunghwan Kim,Younho Lee, Jun Woo Kim,Young-Jin Son, Min Jung Ma, Jee-Hyun Um,Nam Doo Kim,Sang Hyun Min,Dong Il Kim, Brian B Kim

PloS one, no. 6 (2018)

Cited by1WOSBibtex

Inhibitory Effects of 2N1HIA (2-(3-(2-Fluoro-4-Methoxyphenyl)-6-Oxo-1(6H)-Pyridazinyl)- N -1H-Indol-5-Ylacetamide) on Osteoclast Differentiation via Suppressing Cathepsin K Expression

Sun-Hee Ahn, Zhihao Chen, Jinkyung Lee, Seok-Woo Lee,Sang Hyun Min,Nam Doo Kim,Tae-Hoon Lee

MOLECULES, no. 12 (2018)

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BCPA { N , N '-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1

Eugene Cho, Jin-Kyung Lee, Jee-Young Lee, Zhihao Chen, Sun-Hee Ahn,Nam Doo Kim,Min-Suk Kook, Sang Hyun Min, Byung-Ju Park,Tae-Hoon Lee

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, no. 11 (2018)

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BCPA {N,N′-1,4-Butanediylbis[3-(2-chlorophenyl)acrylamide]} Inhibits Osteoclast Differentiation through Increased Retention of Peptidyl-Prolyl cis-trans Isomerase Never in Mitosis A-Interacting 1

Eugene Cho, Jin-Kyung Lee, Jee-Young Lee, Zhihao Chen, Sun-Hee Ahn,Nam Doo Kim,Min-Suk Kook,Sang Hyun Min,Byung-Ju Park,Tae-Hoon Lee

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, no. 11 (2018): 3436

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Identification of TG100-115 as a new and potent TRPM7 kinase inhibitor, which suppresses breast cancer cell migration and invasion

Chiman Song, Yeonju Bae, Jin Joo Jun, Hyomin Lee, Hyomin Lee,Nam Doo Kim, Kyung Bok Lee,Wooyoung Hur,Wooyoung Hur,Jae-Yong Park,Taebo Sim,Taebo Sim

Biochimica et Biophysica Acta (BBA) - General Subjects, no. 4 (2017): 947-957

Cited by8Bibtex

A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells

Han Eun Hee, Min Jin-Young, Yoo Shin-Ae,Park Sung-Joon, Choe Yun-Jeong, Yun Hee Sub,Lee Zee-Won,Jin Sun Woo,Kim Hyung Gyun,Jeong Hye Gwang, Kim Hyun Kyoung,Kim Nam Doo

Oncotarget, no. 41 (2017)

Cited by1WOSBibtex

Identification of a novel 5-amino-3-(5-cyclopropylisoxazol-3-yl)-1-isopropyl-1H-pyrazole-4-carboxamide as a specific RET kinase inhibitor

Hojong Yoon, Injae Shin, Yunju Nam,Nam Doo Kim, Kyung-Bok Lee,Taebo Sim

European Journal of Medicinal Chemistry, (2017): 1145-1155

Cited by5WOSBibtex

Characterization of a highly selective inhibitor of the Aurora kinases

Fleur M Ferguson, Zainab M Doctor,Apirat Chaikuad,Taebo Sim,Nam Doo Kim,Stefan Knapp,Nathanael S Gray

Bioorganic & Medicinal Chemistry Letters, no. 18 (2017): 4405-4408

Cited by1WOSBibtex

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Papers70 papers

Nam Doo Kim