In summary, Dr. Tustison manipulates arrays of numbers with medical relevance; more specifically, as a member of the UVA Medical Imaging Research Department, he develops computational techniques for facilitating quantitation of anatomical and/or functional variability in different populations or over time as a consequence of disease or injury. Areas of active research include various projects with neuroradiology faculty, collaborative pulmonary research using hyperpolarized gases, and the open source dissemination of useful image analysis algorithms. The primary venue for the latter is the Insight Toolkit (ITK) of the National Institutes of Health with which Dr. Tustison has a history of development.