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My research focusses on the mechanisms of collagen mineralization in bone formation and in pathological calcification, where I use creative approaches to study the structural and (bio)chemical aspects of these processes with the highest spatial and temporal resolution.
Unraveling the molecular mechanisms of biological mineralization processes is of the greatest importance for the development of new therapeutic approaches that will help to shift treatments form surgical intervention to prevention.
To study the biological processes as close as possible to the native conditions we emulate matrix formation and mineralization using human, both bone-based in vitro systems, as well as 3D cell culture systems including organoids and bone-on-a-chip devices. We monitor these processes with a variety of advanced microscopic and spectroscopic methods to cover all relevant length and time scales
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论文共 388 篇作者统计合作学者相似作者
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bioRxiv (Cold Spring Harbor Laboratory) (2024)
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 7 (2023)
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NANO LETTERSno. 23 (2023): 11091-11098
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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biorxiv(2022)
Nico Sommerdijk,Marit de Beer,Deniz Daviran,Rona Roverts,Luco Rutten, Elena Macias Sanchez, Jurriaan Metz,Anat Akiva
crossref(2022)
Robin Hendrik Marinus Van der Meijden,Deniz Daviran,Luco Rutten,Frank Walboomers,Elena Macias-Sanchez,Nico Sommerdijk,Anat Akiva
biorxiv(2022)
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