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Research Interests / Professional Overview
Dr. Partridge’s research focuses on parathyroid hormone (PTH) regulation of gene expression by the osteoblast. In one project, her laboratory is investigating how PTH, acting through protein kinase A (PKA) signals to the nucleus of osteoblasts to regulate transcription of a gene, receptor activator of nuclear factor kappa B ligand (RANKL), which is involved in activation of osteoclasts and thus, stimulates bone breakdown. In a second project, Dr. Partridge’s laboratory is examining how PKA regulates bone development, mass, and gene expression and its requirement for the anabolic effects of PTH and the new osteoanabolic, abaloparatide. All of this latter project is in vivo in mice.
Dr. Partridge’s research focuses on parathyroid hormone (PTH) regulation of gene expression by the osteoblast. In one project, her laboratory is investigating how PTH, acting through protein kinase A (PKA) signals to the nucleus of osteoblasts to regulate transcription of a gene, receptor activator of nuclear factor kappa B ligand (RANKL), which is involved in activation of osteoclasts and thus, stimulates bone breakdown. In a second project, Dr. Partridge’s laboratory is examining how PKA regulates bone development, mass, and gene expression and its requirement for the anabolic effects of PTH and the new osteoanabolic, abaloparatide. All of this latter project is in vivo in mice.
研究兴趣
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JOURNAL OF THE ENDOCRINE SOCIETYno. 1 (2023): bvad156-bvad156
JOURNAL OF BONE AND MINERAL RESEARCH (2023): 71-71
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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CELL CALCIUM (2022)
Reference Module in Life Sciencespp.30-38, (2022)
American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodonticsno. 3 (2022): 378-388.e1
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