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I study the communication of innate immune cells with their environment and am particularly interested in G protein-coupled receptors (GPCRs) and the cellular consequences of their activation. The genetic locus of the orphan GPCR GPR35 and a coding variant of the receptor have been associated with risk for inflammatory bowel disease and primary sclerosing cholangitis. However, GPR35’s endogenous, relevant ligands and its function remain enigmatic. Via specific, consciously designed and specific lipopeptides, I aim to modulate GPR35 function to reveal its biological function and will investigate whether its genetic dysfunction can be corrected chemically via pharmacological manipulation of the risk variant.
I study the communication of innate immune cells with their environment and am particularly interested in G protein-coupled receptors (GPCRs) and the cellular consequences of their activation. The genetic locus of the orphan GPCR GPR35 and a coding variant of the receptor have been associated with risk for inflammatory bowel disease and primary sclerosing cholangitis. However, GPR35’s endogenous, relevant ligands and its function remain enigmatic. Via specific, consciously designed and specific lipopeptides, I aim to modulate GPR35 function to reveal its biological function and will investigate whether its genetic dysfunction can be corrected chemically via pharmacological manipulation of the risk variant.
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Anika Agarwal,Lidija Covic, Leila M. Sevigny,Nicole C. Kaneider, Katherine Lazarides, Gissou Azabdaftari, Sheida Sharifi,Athan Kuliopulos
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Anika Agarwal,Lidija Covic, Leila M. Sevigny,Nicole C. Kaneider, Katherine Lazarides, Gissou Azabdaftari, Sheida Sharifi,Athan Kuliopulos
crossref(2023)
Anika Agarwal,Lidija Covic, Leila M. Sevigny,Nicole C. Kaneider, Katherine Lazarides, Gissou Azabdaftari, Sheida Sharifi,Athan Kuliopulos
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