基本信息
浏览量:28
职业迁徙
个人简介
Research Interests
The development, maintenance and proper function of immune cells is essential for the survival of mammals in a pathogen-ridden environment. Their absence results in inherited or acquired immunodeficiency, the latter of which is the basis of a growing health crisis. Conversely, deregulated growth and development can lead to cancer of the immune system. Lung cancer is the leading cause of death by cancer among Canadians.
Our research focus is on airway immunity as regulated by the interleukin-7 (IL-7)-related cytokines, IL-7 and Thymic Stromal Lymphopoietin (TSLP). IL-7 is an essential growth factor for lymphocytes. Defects in IL-7 or its deregulation cause immunodeficiency and lymphomas respectively. TSLP is a barrier integrity cytokine or alarmin, that is also implicated in barrier repair and atopic diseases such as asthma. Our long-term goal is to use genetic models of IL-7 and TSLP function to understand the basic mechanisms that contribute to these diseases and to formulate novel therapeutic strategies.
The development, maintenance and proper function of immune cells is essential for the survival of mammals in a pathogen-ridden environment. Their absence results in inherited or acquired immunodeficiency, the latter of which is the basis of a growing health crisis. Conversely, deregulated growth and development can lead to cancer of the immune system. Lung cancer is the leading cause of death by cancer among Canadians.
Our research focus is on airway immunity as regulated by the interleukin-7 (IL-7)-related cytokines, IL-7 and Thymic Stromal Lymphopoietin (TSLP). IL-7 is an essential growth factor for lymphocytes. Defects in IL-7 or its deregulation cause immunodeficiency and lymphomas respectively. TSLP is a barrier integrity cytokine or alarmin, that is also implicated in barrier repair and atopic diseases such as asthma. Our long-term goal is to use genetic models of IL-7 and TSLP function to understand the basic mechanisms that contribute to these diseases and to formulate novel therapeutic strategies.
研究兴趣
论文共 88 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Melina Messing,Dominique M Gatti, Siavash Mashhouri,Sabryna Nantel, Saki Sultana, Lauren P Westhaver, Kamala D Patel,Aaron J Marshall, S M Mansour Haeryfar, Craig N Jenne,Ninan Abraham,Heather J Melichar,
Journal of immunology (Baltimore, Md. : 1950)no. 8 (2024): 1257-1267
Journal of Thoracic Oncologyno. 6 (2022): 734-736
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn