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Our laboratory uses mass spectrometry to answer questions about protein structure, protein purity, and protein modifications. We have developed methods to identify protein modifications resulting from exposure to organophosphorus pesticides and nerve agents. These poisons make adducts not only on acetylcholinesterase and butyrylcholinesterase, but also on albumin. The information gained from studying protein adducts is useful for proving exposure and for identifying the type of poison. Low doses that cause no symptoms can nevertheless be detected by analyzing blood samples.
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BIOCHEMISTRY RESEARCH INTERNATIONAL (2024): 7120208-7120208
Current protocolsno. 2 (2023): e672-e672
Biochemical Pharmacology (2023): 115910-115910
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