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We are interested in answering the question: “what makes organisms the way that they are?” To this end, our lab focuses on understanding the genotype-phenotype map: how genetic information contained within DNA is translated into the whole organism that interacts in the real world. We use the model nematode C. elegans and its relatives to pursue the molecular genetics of this map for traits such as body size, reproductive success, sexual interactions, longevity, and the behavioral response to temperature and chemicals. The other part to this answer is understanding how the genetic system itself is molded by the evolutionary process. To investigate this, we use experimental evolution and whole genome analysis within laboratory populations of nematodes to identify the genetic basis of the response to selection, and theoretical approaches to study the evolution of gene interaction systems and suites of coevolving traits. We also explore a wide variety of questions in evolutionary genetics, including the role that sexual reproduction and outcrossing play in shaping the pattern of genetic variation and influencing the rate of evolutionary change within natural populations.
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论文共 177 篇作者统计合作学者相似作者
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Lab on a chip (2024)
GeroScienceno. 2 (2024): 2239-2251
GENOME BIOLOGY AND EVOLUTIONno. 2 (2024)
Megan J Moerdyk-Schauwecker, Erin K Jahahn, Zachariah I Muñoz, Kristin J Robinson,Patrick C Phillips
microPublication biology (2024)
G3-GENES GENOMES GENETICSno. 2 (2024)
Agingno. 7 (2024): 5829-5855
bioRxiv : the preprint server for biology (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Monica Driscoll,Brian Onken, Yunpeng Xu, Yuhua Song, Madhuri Achanta,Christine Sedore,Patrick Phillips,Gordon Lithgow
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