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We are studying the novel, RNA-based pathways and virus-host interactions underlying replication, gene expression and evolution by positive-strand RNA viruses, the largest class of viruses. Positive strand RNA viruses include many important human pathogens such as hepatitis C virus, which chronically infects nearly 3% of the world population, causing progressive liver damage and liver cancer, and the new SARS coronavirus. We are also studying selected replication processes of a reverse-transcribing virus, hepatitis B virus, which is also a major human tumor virus. Our studies integrate molecular genetics, genomics, biochemistry and cell biology to address fundamental questions in virus replication and virus-cell interactions.
Viruses are divided into six distinct classes differing in the type of nucleic acid in the virus particle and its replication pathways. Recently, we discovered multiple, detailed structural and functional parallels among the replication complexes of three of these six virus classes: positive-strand RNA viruses, retroviruses and dsRNA viruses. These results imply a significant functional and evolutionary unification within virology, and have opened the door to many exciting new experimental questions and approaches that we are now pursuing.
We also have identified the first higher eukaryotic viruses that can direct genome replication, gene expression and virion assembly in the genetically tractable yeastSaccharomyces cerevisiae. Using yeast genetics and genomics, we are identifying a growing number of host genes required for viral RNA replication and are studying how these function with virus-encoded helicase- and polymerase-like replication factors and diverse cis-acting viral RNA signals to direct assembly and function of the membrane-bound viral genome replication complexes and other processes.
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论文共 158 篇作者统计合作学者相似作者
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Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon, Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth, Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,
crossref(2023)
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. 29 Suppl 1 (2023): 904-905
bioRxiv (Cold Spring Harbor Laboratory) (2023)
mBiono. 5 (2023)
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Dohun Pyeon,Michael A. Newton,Paul F. Lambert,Johan A. den Boon, Srikumar Sengupta,Carmen J. Marsit,Craig D. Woodworth, Joseph P. Connor,Thomas H. Haugen,Elaine M. Smith,Karl T. Kelsey,Lubomir P. Turek,
crossref(2023)
James W Bruce, Eunju Park, Chris Magnano,Mark Horswill,Alicia Richards,Gregory Potts,Alexander Hebert, Nafisah Islam,Joshua J Coon,Anthony Gitter,Nathan Sherer,Paul Ahlquist
PLoS pathogensno. 7 (2023): e1011492-e1011492
Srikumar Sengupta,Johan A. den Boon, I-How Chen,Michael A. Newton, David B. Dahl, Meng Chen,Yu-Juen Cheng,William H. Westra,Chien-Jen Chen,Allan Hildesheim,Bill Sugden,Paul Ahlquist
crossref(2023)
Roma Broadberry,Hong Zhan, Nurrudin Unchwaniwala,Andrea Rebolledo-Viveros,Mark Horswill, Johnathan Meyers,Johan den Boon,Paul Ahlquist, Tim Grant
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canadano. Supplement_1 (2023): 936-936
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Srikumar Sengupta,Johan A. den Boon, I-How Chen,Michael A. Newton,David B. Dahl, Meng Chen,Yu-Juen Cheng,William H. Westra,Chien-Jen Chen,Allan Hildesheim,Bill Sugden,Paul Ahlquist
crossref(2023)
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