基本信息
浏览量:0
职业迁徙
个人简介
Research in our laboratory focuses on the biochemistry and biophysics of amyloid plaques and their relationship to sporadic and familial forms of Alzheimer’s disease. Plaques are a principal pathological feature of Alzheimer’s disease and appear as abnormal accumulations of fibrous or thread-like structures within the brain. These plaques are assembled by the misfolding and aggregation of the amyloid-beta (Abeta) protein. We have been studying its properties with an emphasis on the factors responsible for the transition from the normal to diseased fibrous state, the ability of aggregated Abeta‚ to kill nerve cells in culture, and the mechanism by which this is accomplished. Considerable advances have been made in this area and we are expanding our efforts to look for modulators of plaque formation as well as the cellular receptors which we feel are responsible for amyloid’s “killer” action. Our ultimate goal is to understand the events that culminate in these abnormal and detrimental proteins and the development of drugs capable of controlling these processes. These investigations are relevant to both the sporadic and familial forms of Alzheimer’s disease which exhibit identical amyloid pathology but differ only in their rate of progression.
研究兴趣
论文共 268 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Melissa K. Eccles, Nathan Main,Rodrigo Carlessi,Ayeisha Milligan Armstrong,Miheer Sabale, Brigid Roberts-Mok,Janina E. E. Tirnitz-Parker,Mark Agostino,David Groth,Paul E. Fraser,Giuseppe Verdile
FASEB JOURNALno. 1 (2024)
Melissa K Eccles, Nathan Main, Rodrigo Carlessi, Ayeisha Milligan Armstrong,Miheer Sabale, Brigid Roberts-Mok, Janina E E Tirnitz-Parker,Mark Agostino,David Groth,Paul E Fraser,Giuseppe Verdile
FASEB journal : official publication of the Federation of American Societies for Experimental Biologyno. 1 (2024): e23396-e23396
Elliya Park,Lily Yi Li,Chunsheng He,Azhar Z Abbasi,Taksim Ahmed,Warren D Foltz, Regan O'Flaherty,Maham Zain,Robert P Bonin,Andrew M Rauth,Paul E Fraser,Jeffrey T Henderson,
Victor Bodart-Santos, Lisandra S Pinheiro,Almir J da Silva-Junior,Rudimar L Froza,Rosemary Ahrens,Rafaella A Gonçalves, Mayara M Andrade,Yan Chen,Carolina de Lima Alcantara,Lea T Grinberg,Renata E P Leite,Sergio T Ferreira,
ALZHEIMERS & DEMENTIAno. 12 (2023): 5418-5436
Giselle de Andrade Ramos,Andressa Souza de Oliveira,Manuela Bartolini,Marina Naldi,Irene Liparulo,Christian Bergamini,Elisa Uliassi,Ling Wu,Paul E Fraser, Monica Abreu,Alessandra Sofia Kiametis,Ricardo Gargano,
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn