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个人简介
Paul J. Thornalley is an international diabetes researcher. His studies focus on metabolic dysfunction driving the development of insulin resistance, obesity, type 2 diabetes and diabetic vascular complications.
Research Interests
Metabolic dysfunction driving the development of insulin resistance and obesity, type 2 diabetes and diabetic vascular complications: (i) hexokinase-2 linked unscheduled glycolysis and glycolytic overload, and (ii) increased methylglyoxal (MG), “dicarbonyl stress”, protein glycation by MG and activation of the unfolded protein response
Development of glyoxalase 1 inducers for prevention and treatment of diabetes and vascular complications of diabetes and healthy aging
Protein glycation and oxidation biomarkers for clinical diagnostic applications in diabetes and other conditions
Other: development of glyoxalase 1 inhibitor therapeutics for treatment of multidrug resistant tumors and repurposing of glyoxalase-1 based therapeutics for COVID-19
研究兴趣
论文共 520 篇作者统计合作学者相似作者
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REDOX BIOLOGY (2024): 103025-103025
FRONTIERS IN ENDOCRINOLOGY (2024): 1268308-1268308
Shadi Nejat,Kalhara R. Menikdiwela, Aliyah Efotte,Shane Scoggin,Bolormaa Vandanmagsar,Paul J. Thornalley,Mohammed Dehbi,Naima Moustaid-Moussa
Genesno. 10 (2023): 1857-1857
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Aisha Nasser J. M. Al-Saei,Wared Nour-Eldine,Kashif Rajpoot, Noman Arshad,Abeer R. Al-Shammari,Madeeha Kamal, Ammira Al-Shabeeb Akil,Khalid A. Fakhro,Paul J. Thornalley,Naila Rabbani
MOLECULAR PSYCHIATRYpp.1-7, (2023)
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