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We have discovered a novel translational control pathway that selectively regulates inflammatory gene expression in myeloid cells, and may be an endogenous regulator of the duration and magnitude of the inflammatory response. IFN-gamma induces expression of certain pro-inflammatory mRNAs, e.g., vascular endothelial growth factor (VEGF)-A and ceruloplasmin, but synthesis of the proteins is limited by translational silencing. IFN-gamma induces assembly of the 4-protein, IFN-Gamma-Activated Inhibitor of Translation (GAIT) complex, that binds a specific RNA element in the 3’untranslated region of target mRNAs, and inhibits translation. We are investigating the signal transduction pathways that lead to activation of the GAIT system, the mechanisms by which two of the proteins escape their parent complexes, and the in vivo function of the pathway. Also, we are taking a ribonomic approach to elucidate the family of targets silenced by this pathway.
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Virusesno. 3 (2024): 468
BioEssays : news and reviews in molecular, cellular and developmental biologyno. 5 (2023)
Debjit Khan,Fulvia Terenzi,GuanQun Liu, Prabar K. Ghosh,Fengchun Ye,Kien Nguyen,Arnab China,Iyappan Ramachandiran, Shruti Chakraborty, Jennifer Stefan,Krishnendu Khan,Kommireddy Vasu,
Kommireddy Vasu,Iyappan Ramachandiran, Aayushi Chechi,Krishnendu Khan,Debjit Khan, Randall Kaufman,Paul L Fox
RNA biologyno. 1 (2023): 737-749
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BIOCHEMICAL SOCIETY TRANSACTIONSno. 6 (2023): 2127-2141
Katie M Troike, Sabrina Z Wang,Daniel J Silver,Juyeun Lee,Erin E Mulkearns-Hubert, Nicole Hajdari, Prabar K Ghosh,Kristen E Kay, Julia L Beilis, Sofia E Mitchell, Christopher W Bishop, Ellen S Hong,
Neuro-oncology advancesno. 1 (2023): vdad154-vdad154
MOLECULAR CELLno. 21 (2023): 3941-3941
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