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The Lindahl lab is interested in the cellular biochemistry of iron and copper. Transition metals have exceptional redox and catalytic properties that render them indispensable for life. However, they also help generate reactive oxygen species which damage cells and contribute to aging and disease. Thus, cells must tightly regulate metal-ion trafficking. There are huge gaps in understanding the biochemistry of metal ion trafficking and regulation in cells, and we are developing innovative and powerful approaches to fill them. The “Grand Central Station” of Fe trafficking is the cytosolic Labile Fe Pool.
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iScienceno. 1 (2024): 108506-108506
The Journal of biological chemistryno. 12 (2023): 105435-105435
Rachel E. E. Shepherd,Alexia C. C. Kreinbrink,Cybele Lemuh Njimoh,Shaik Waseem Vali,Paul A. A. Lindahl
Journal of the American Chemical Societyno. 25 (2023): 13556-13569
Journal of Biological Chemistryno. 12 (2022): 102667-102667
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