Paul’s main primary research focus is on using Systems Biology approaches to identify key functionalities of microbial communities including human-associated microbiota. His group has pioneered appropriate methodologies for carrying out systematic molecular measurements of microbial consortia over space and time. This allows, for example, to define lifestyle strategies of distinct populations and link these to genetic and functional traits. The same approaches allow the study of microbiome-host molecular interactions. In this context, his group has pioneered the development of a microfluidics-based in vitro model of the human-microbial gastrointestinal interface called HuMiX.

Paul has authored more than 80 peer-review publications. He is a frequently invited speaker at international scientific symposia and academic institutions. Paul is a member of several national and international scientific organizations, and he has won several prizes for his scientific work.