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Professor Hillmen has research interests in both paroxysmal nocturnal haemoglobinuria (PNH) and chronic lymphocytic leukaemia (CLL). Since 1990 he has continued to research into PNH that eventually led to the development of anti-complement therapy for PNH. He was the lead on the trials of eculizumab and now leads the National PNH Service based in Leeds and Kings. The National PNH service looks after over 300 patients with PNH and this provides a unique resource for continued research into the pathophysiology and therapy of PNH. Since 1995 Professor Hillmen has had an interest in understanding the pathophysiology of and in developing novel therapies for CLL. His group has pioneered the use of minimal residual disease assessment in CLL and he Chairs the NCRI CLL sub-group in the UK responsible for the development of UK CLL Clinical Trials. He initially studied chemo-immunotherapeutic approaches for CLL but recently the development of targeted small molecules, particularly of the B-cell receptor pathway and of apoptosis, has led to a dramatic change in the treatment of CLL. His research is now focussing on the mechanism of action of these targeted therapies in order to maximise their potential.
研究兴趣
论文共 812 篇作者统计合作学者相似作者
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Austin Kulasekararaj,Jamie Cavenagh,Inderjeet Dokal, Theodora Foukaneli, Shreyans Gandhi,Mamta Garg,Morag Griffin,Peter Hillmen,Robin Ireland,Sally Killick,Sahar Mansour,Ghulam Mufti,
BRITISH JOURNAL OF HAEMATOLOGYno. 3 (2024): 784-804
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BRITISH JOURNAL OF HAEMATOLOGY (2023): 14-15
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Andy Rawstron,Nichola Webster,David Allsup,Sue Bell,Adrian Bloor,David Cairns,Anna Hockaday,Sharon Jackson,Surita Dalal,Ruth de Tute, Natasha Greatorex, Rhiannon Lambkin,
LEUKEMIA & LYMPHOMA (2023): S19-S20
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