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His general research area was: “Biochemical and Molecular Toxicology – Mechanisms of Drug-Induced Cytotoxicity and Its Prevention”. Here is a summary of his research interests from the University of Toronto website. “Most drugs have a limited dosage as a result of toxic side effects that develop following chronic use. Toxicity also occurs when higher doses are administered accidentally or deliberately. Drugs chosen for their toxicity towards tumor cells can also cause toxicity towards normal tissues. Peter’s research explored ways of decreasing the toxicity of drugs or naturopathic agents. His approaches included the use of less toxic drug analogues, antidotes, improving the nutritional status of the patient and targeting of the drug to the tissue that requires therapy. He also investigated the molecular mechanisms by which some natural products or drugs could prevent the development of cancer (chemoprevention). An example of a common drug candidate cytotoxic mechanism was mitochondrial toxicity that caused reductive stress and ATP depletion, released iron and activated oxygen.”
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Kai Yang, Sara Fard,Rudolf Furrer,Michael C Archer,W Robert Bruce,HoYin Lip,Rhea Mehta,Peter J O'Brien,Adria Giacca,Wendy E Ward, A Pietro Femia,Giovanna Caderni,
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