As a physician scientist, Dr Todd’s lab studies the mechanisms by which nucleotide repeat expansions cause neurodevelopmental and neurodegenerative disorders with a long term goal of developing novel therapeutics for currently untreatable conditions. His lab has published extensively on Fragile X-associated disorders, such as Fragile X Syndrome and Fragile X-associated Tremor/Ataxia Syndrome (FXTAS) as well as C9orf72 repeat expansions that cause ALS and frontotemporal dementia. Recent research is also exploring the roles of repeat expansions in more common neurological diseases. His lab has been continuously funded by the NIH and VA since its inception and he serves as co-director of one of three National Fragile X Research Centers established by the NIH in 2020.