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Our laboratory is primarily focusing on developing and applying solution-state NMR methods, together with computational and biochemical approaches, to understand the molecular basis of RNA function. In particular, we aim to visualize, with atomic resolution, the entire dynamic process of ribozyme catalysis, riboswitch-based gene regulation, and co-transcriptional folding of mRNA. The principles deduced from these studies will provide atomic basis for rationally manipulating RNA catalysis and folding, and for de novo design of small molecules that target specific RNA signals involving in cancer and human disease. Research program in the laboratory provides diverse training opportunities in areas of spectroscopy, biophysics, structural biology, computational modeling, and biochemistry.
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