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Cortical Circuits and Dendritic Spines
The goal of our laboratory is to understand the function of the cortical microcircuit. The cortex constitutes the larger part of the brain in mammals. In humans it is the primary site of mental functions like perception, memory, control of voluntary movements, imagination, language and music. No accepted unitary theory of cortical function exists yet; nevertheless, the basic cortical microcircuitry develops in stereotyped fashion, is similar in different cortical areas and in different species, and has apparently not changed much in evolution since its appearance. At the same time, the cortex participates in apparently widely different computational tasks, resembling a "Turing machine". Because of this, it is conceivable that a "canonical" cortical microcircuit may exist and implement a relatively simple, and flexible, computation.
We attempt to reverse-engineer the cortical microcircuit using brain slices from mouse neocortex as our experimental preparation. The techniques applied are electrophysiology, anatomy, and a variety of optical methods, including infrared-DIC, voltage- and ion-sensitive dye imaging with confocal, two-photon and second harmonic microscopy. We also use laser uncaging, biolistics, electroporation, electron microscopy and numerical simulations, and make extensive use of genetically modified mouse strains.
The goal of our laboratory is to understand the function of the cortical microcircuit. The cortex constitutes the larger part of the brain in mammals. In humans it is the primary site of mental functions like perception, memory, control of voluntary movements, imagination, language and music. No accepted unitary theory of cortical function exists yet; nevertheless, the basic cortical microcircuitry develops in stereotyped fashion, is similar in different cortical areas and in different species, and has apparently not changed much in evolution since its appearance. At the same time, the cortex participates in apparently widely different computational tasks, resembling a "Turing machine". Because of this, it is conceivable that a "canonical" cortical microcircuit may exist and implement a relatively simple, and flexible, computation.
We attempt to reverse-engineer the cortical microcircuit using brain slices from mouse neocortex as our experimental preparation. The techniques applied are electrophysiology, anatomy, and a variety of optical methods, including infrared-DIC, voltage- and ion-sensitive dye imaging with confocal, two-photon and second harmonic microscopy. We also use laser uncaging, biolistics, electroporation, electron microscopy and numerical simulations, and make extensive use of genetically modified mouse strains.
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bioRxiv : the preprint server for biology (2024)
Current opinion in neurobiology (2024): 102869-102869
Neuronno. 6 (2024): 875-892
Nicola Masala,Manuel Mittag,Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian Distler,Peter Rupprecht,Fritjof Helmchen,Rafael Yuste,Martin Fuhrmann,Heinz Beck,Michael Wenzel,Tony Kelly
bioRxiv : the preprint server for biology (2024)
Nicola Masala,Manuel Mittag,Eleonora Ambrad Giovannetti, Darik A O'Neil, Fabian Distler,Peter Rupprecht,Fritjof Helmchen,Rafael Yuste,Martin Fuhrmann,Heinz Beck,Michael Wenzel,Tony Kelly
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Nature communicationsno. 1 (2024): 3192-3192
Alison Hanson, Raphael Reme, Noah Telerman,Wataru Yamamoto,Jean-Christophe Olivo-Marin,Thibault Lagache,Rafael Yuste
Scientific Reportsno. 1 (2024): 1-15
Current Opinion in Neurobiology (2024): 102869
Rafael Yuste, Tomás de la Quadra-Salcedo
Indiana Journal of Global Legal Studiesno. 1 (2023): 15-37
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STAR PROTOCOLSno. 3 (2023): 102543-102543
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