基本信息
浏览量:1
职业迁徙
个人简介
The Rao laboratory studies the role of novel ion transporters in human health and disease. One project focuses on the calcium signaling in breast cancer. We showed that an isoform of the secretory pathway Ca2+-ATPase, SPCA2, interacts with ion channels to drive tumor proliferation. We are currently investigating how downregulation of SPCA2 promotes epithelial to mesenchymal transition. A second project relates to the endosomal Na+/H+ exchangers NHE6 and NHE9 that are linked to autism, Christianson syndrome, ADHD and a growing list of neurodevelopmental and neurodegenerative disorders. We use a powerful PheWAS approach combined with model structure-driven evolutionary conservation analysis and functional screening of human variants to identify, evaluate and predict causality of autism-associated mutations. Loss of eNHE function results in hyperacidic endosomes, which increases amyloidogenic processing, and turnover of cell surface receptors and neurotransmitter transporters to impact neurotransmitter uptake and synaptic development. On the other hand, overexpression of NHE9 in glioblastoma confers chemoradiation resistance due to “inside out” control of oncogenic signaling. Our lab also discovered NHA2, an unusual Na+/H+ exchanger that is implicated in essential hypertension and plays a role in salt handling in the kidney. We make extensive use of 3D/organoid cultures, confocal microscopy, live cell calcium and pH imaging, and phenotype complementation in yeast to investigate mammalian transport proteins.
研究兴趣
论文共 134 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
PNAS NEXUSno. 1 (2023)
Junyi Zou,Koushambi Mitra,Palapuravan Anees,Daphne Oettinger, Joseph R Ramirez,Aneesh Tazhe Veetil, Priyanka Dutta Gupta,Rajini Rao,Jayson J Smith,Paschalis Kratsios,Yamuna Krishnan
Nature biotechnologypp.1-9, (2023)
biorxiv(2022)
Monish Ram Makena,Myungjun Ko, Allatah X Mekile, Nanami Senoo,Donna K Dang, John Warrington, Phillip Buckhaults,C Conover Talbot, Steven M Claypool,Rajini Rao
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn