基本信息
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职业迁徙
个人简介
The primary research interest of the DeBerardinis laboratory is the role of altered
metabolic states in human diseases, including cancer and inborn metabolic diseases in children. We have extensive experience measuring metabolic flux in vitro, in vivo and ex vivo. By using a combination of mass spectrometry and NMR spectroscopy, we have developed the ability to provide extremely sensitive, specific and comprehensive views of intermediary metabolism in biological systems. We have used these approaches to identify a number of novel regulatory mechanisms, and novel metabolic pathways that support the ability of tumor cells to produce macromolecules and sustain proliferation and viability. We are now using metabolic flux analysis to understand the full breadth of metabolic diversity in cancer, and are applying these data sets to understand the molecular determinants of metabolic pathway choice and metabolic vulnerabilities. These studies are complemented by in vivo analysis of metabolism in mice and patients, and by translational efforts designed to understand and exploit metabolic idiosyncrasies of tumor cells. Emerging work explores the utility of combining metabolic analysis with molecular imaging techniques to monitor metabolic states non-invasively and to discover the drivers of metabolic phenotypes in vivo. In inborn errors of metabolism, we use genomics and metabolomics to identify novel disease genes and develop therapies, including dietary modifications, to treat these conditions. My trainee history includes undergraduates, pre-doctoral students and post-doctoral scientists, most of whom have remained engaged in research after moving on from my lab.
Other Experience and Professional Memberships
2000 – present Member, American Academy of Pediatrics
2002 – present Member, American Society of Human Genetics
2004 – present Member, United Mitochondrial Disease Foundation
2007 – present Member, Society for Inherited Metabolic Disorders
2009 – present Member, American Association for Cancer Research
2009 – present Member, Society for Pediatric Research
2009 – present Faculty, Genetics and Development Graduate Group, UT Southwestern
2009 – present Faculty, Cancer Biology Graduate Group, UT Southwestern
2011 – present Program Committee (Cellular and Molecular Biology Section, Metabolism and Cancer
Subcommittee), American Association for Cancer Research
2012 – 2016 Editorial Board, Oncogene
2014 – present Editorial Board, Cancer Discovery
2014 – present Editorial Board, EMBO Molecular Medicine
2014 – present Senior Editor, Cancer & Metabolism
2016 – present Board of Reviewing Editors, eLife
2014 – 2018 Deputy Editor, Molecular Case Studies, Cold Spring Harbor Press
2015 – present Keystone Symposia Study Group
2016 Steering Committee, AACR Cancer Progress Report
2019 – present External Advisory Board, Rutgers Comprehensive Cancer Center
Honors
1994-2000 University of Pennsylvania Franklin Scholar (MD/PhD support)
1998 Roy G. Williams Award for research in the basic sciences, University of Pennsylvania
2003 Senior Resident Clinician Award, Children’s Hospital of Philadelphia
2004-2006 University of Pennsylvania Medical Genetics T32
2007 Children’s Hospital of Philadelphia Faculty Honor Roll
2008 Society for Inherited Metabolic Disorders, Neil Buist Award
2008 William K. Bowes, Jr. Award in Medical Genetics, Harvard-Partners Center
2008 President’s Research Council Young Researcher Award, UT Southwestern
2008 Sowell Family Scholar in Medical Research, UT Southwestern
2011 Damon Runyon Cancer Research Foundation Clinical Investigator Award
2012 American Society for Clinical Investigation
2013 Joel B. Steinberg, M.D. Chair in Pediatrics
2015 – 2016 Chair, Metabolism and Cancer Section, 2016 American Association for Cancer
Research Program Committee
2016 Faculty Scholar, Howard Hughes Medical Institute2016 D Magazine, Best Doctors and Pediatric Subspecialists
2017 Outstanding Investigator Award, National Cancer Institute, NIH
2017 Inaugural Robert L. Moody, Sr. Faculty Scholar
2018 Investigator, Howard Hughes Medical Institute
2018 Edith and Peter O’Donnell Award in Medicine, The Academy of Medicine, Engineering
and Science of Texas
2019 Post-doctoral mentoring award, UT Southwestern Medical Center
2020 Association of American Physicians
metabolic states in human diseases, including cancer and inborn metabolic diseases in children. We have extensive experience measuring metabolic flux in vitro, in vivo and ex vivo. By using a combination of mass spectrometry and NMR spectroscopy, we have developed the ability to provide extremely sensitive, specific and comprehensive views of intermediary metabolism in biological systems. We have used these approaches to identify a number of novel regulatory mechanisms, and novel metabolic pathways that support the ability of tumor cells to produce macromolecules and sustain proliferation and viability. We are now using metabolic flux analysis to understand the full breadth of metabolic diversity in cancer, and are applying these data sets to understand the molecular determinants of metabolic pathway choice and metabolic vulnerabilities. These studies are complemented by in vivo analysis of metabolism in mice and patients, and by translational efforts designed to understand and exploit metabolic idiosyncrasies of tumor cells. Emerging work explores the utility of combining metabolic analysis with molecular imaging techniques to monitor metabolic states non-invasively and to discover the drivers of metabolic phenotypes in vivo. In inborn errors of metabolism, we use genomics and metabolomics to identify novel disease genes and develop therapies, including dietary modifications, to treat these conditions. My trainee history includes undergraduates, pre-doctoral students and post-doctoral scientists, most of whom have remained engaged in research after moving on from my lab.
Other Experience and Professional Memberships
2000 – present Member, American Academy of Pediatrics
2002 – present Member, American Society of Human Genetics
2004 – present Member, United Mitochondrial Disease Foundation
2007 – present Member, Society for Inherited Metabolic Disorders
2009 – present Member, American Association for Cancer Research
2009 – present Member, Society for Pediatric Research
2009 – present Faculty, Genetics and Development Graduate Group, UT Southwestern
2009 – present Faculty, Cancer Biology Graduate Group, UT Southwestern
2011 – present Program Committee (Cellular and Molecular Biology Section, Metabolism and Cancer
Subcommittee), American Association for Cancer Research
2012 – 2016 Editorial Board, Oncogene
2014 – present Editorial Board, Cancer Discovery
2014 – present Editorial Board, EMBO Molecular Medicine
2014 – present Senior Editor, Cancer & Metabolism
2016 – present Board of Reviewing Editors, eLife
2014 – 2018 Deputy Editor, Molecular Case Studies, Cold Spring Harbor Press
2015 – present Keystone Symposia Study Group
2016 Steering Committee, AACR Cancer Progress Report
2019 – present External Advisory Board, Rutgers Comprehensive Cancer Center
Honors
1994-2000 University of Pennsylvania Franklin Scholar (MD/PhD support)
1998 Roy G. Williams Award for research in the basic sciences, University of Pennsylvania
2003 Senior Resident Clinician Award, Children’s Hospital of Philadelphia
2004-2006 University of Pennsylvania Medical Genetics T32
2007 Children’s Hospital of Philadelphia Faculty Honor Roll
2008 Society for Inherited Metabolic Disorders, Neil Buist Award
2008 William K. Bowes, Jr. Award in Medical Genetics, Harvard-Partners Center
2008 President’s Research Council Young Researcher Award, UT Southwestern
2008 Sowell Family Scholar in Medical Research, UT Southwestern
2011 Damon Runyon Cancer Research Foundation Clinical Investigator Award
2012 American Society for Clinical Investigation
2013 Joel B. Steinberg, M.D. Chair in Pediatrics
2015 – 2016 Chair, Metabolism and Cancer Section, 2016 American Association for Cancer
Research Program Committee
2016 Faculty Scholar, Howard Hughes Medical Institute2016 D Magazine, Best Doctors and Pediatric Subspecialists
2017 Outstanding Investigator Award, National Cancer Institute, NIH
2017 Inaugural Robert L. Moody, Sr. Faculty Scholar
2018 Investigator, Howard Hughes Medical Institute
2018 Edith and Peter O’Donnell Award in Medicine, The Academy of Medicine, Engineering
and Science of Texas
2019 Post-doctoral mentoring award, UT Southwestern Medical Center
2020 Association of American Physicians
研究兴趣
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Yutaka Furuta,Rory Tinker,Rizwan Hamid,Joy Cogan, Kimberly Ezell,Devin Oglesbee,Ralph DeBerardinis,John Phillips
Molecular Genetics and Metabolismno. 4 (2024): 108282
Qiang Feng,Zachary Bennett, Anthony Grichuk, Raymundo Pantoja,Tongyi Huang,Brandon Faubert,Gang Huang,Mingyi Chen,Ralph J. DeBerardinis,Baran D. Sumer,Jinming Gao
Hai Wei, Yi M. Weaver,Chendong Yang,Yuan Zhang,Guoli Hu, Courtney M. Karner,Matthew Sieber,Ralph J. DeBerardinis,Benjamin P. Weaver
Nature Metabolismno. 1 (2024): 113-126
bioRxiv : the preprint server for biology (2024)
James W Miller,Brandon M Faubert, Thomas P Mathews, John K Waters,Ralph J DeBerardinis, Kemp H Kernstine
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgeryno. 2 (2024)
Hari Shankar Sunil, Barrett L. Updegraff,Jingfei Zhu, Lisa Thomas,Bret M. Evers,Jean R. Clemenceau, Isabel Barnfather,John D. Minna,Ralph J. Deberardinis,Trudy G. Oliver,Tae Hyun Hwang, Kathryn A. O'Donnell
Cancer Researchno. 6_Supplement (2024): 1793-1793
Science advancesno. 13 (2024): eado7808-eado7808
bioRxiv : the preprint server for biology (2024)
Ivan Menendez-Montes,Ashley Solmonson, Ana Helena MAcedo-Pereira,Alisson C. Cardoso,Yuji Nakada,Suwannee Thet,Ralph DeBerardinis,Hesham A. Sadek
CIRCULATION RESEARCH (2023)
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