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Raúl Padrón research focus is on the structure, function and evolution of the myosin interacting-heads motif (IHM) and their implications on human disease. The IHM is established by the interactions of the two heads of the myosin molecule and its myosin tail subfragment-2, forming an asymmetric arrangement that inhibits the ATPases of both heads in the relaxed state. The IHM is conserved since before animals emerged, independently of the muscle type (striated, cardiac or smooth) or in non-muscle cells; showing its fundamental importance as the structural basis underlying relaxation through both heads ATPase inhibition, implying ATP energy-saving via a super-relaxation mechanism. Current focus is on: (1) the study by single-particle cryo-EM of the near atomic structure and function of the IHM from skeletal, smooth and cardiac muscle, and non-muscle cells, and of the IHM on thick filaments of invertebrate skeletal and vertebrate skeletal and cardiac muscle, aiming to understand the implications of the clustering of mutations on human diseases involving the IHM; (2) to study by time-resolved X-ray diffraction the structure and function of the blocked and free heads of the IHM in live relaxed and contracting muscle.
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论文共 129 篇作者统计合作学者相似作者
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Biophysical Journalno. 3 (2024)
Biophysical Journalno. 3 (2024)
The Journal of General Physiology (2021)
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#Papers: 128
#Citation: 3550
H-Index: 27
G-Index: 53
Sociability: 5
Diversity: 2
Activity: 18
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