His research focuses on cognitive aging, Alzheimer’s disease and migraine headaches. He is the Principal Investigator of the Einstein Aging Study, an NIH funded Program Project, and collaborates on several R01s. His research focuses on risk factors and biomarkers of cognitive decline and Alzheimer’s disease. His recent studies examine cognitive aging across the lifespan with an emphasis on the effects of pain and stress on brain function.

His headache research focuses on the epidemiology of migraine and on clinical trials. His epidemiologic studies have evaluated trigger factors for headache attacks and risk factors for headache progression. Dr. Lipton has published more than 800 original articles, many with trainees. He is a 5 time winner of the H.G. Wolff Award for excellence in headache research from the American Headache Society and a two time winner of the Enrico Greppi award from the European Headache Federation. Dr. Lipton is Director of the Montefiore Headache Center, an interdisciplinary subspecialty center focused on headache, patient care, research and education.