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Richard Weinshilboum, M.D. studies pharmacogenomics — the role of inheritance and individual variation in DNA sequence or structure in drug response. The goal is to develop safer and more effective drug therapy to treat diseases that range from cancer to depression.
Dr. Weinshilboum's research program utilizes genomic techniques that include genome-wide association studies (GWAS) and "next-generation" whole genome DNA sequencing using samples from large numbers of patients treated with a specific anticancer or antidepressant drug. Sophisticated cell-based functional genomic techniques are used to determine mechanisms responsible for variation in drug response phenotypes. This approach has already succeeded in the discovery and functional/mechanistic pursuit of novel, unanticipated genes that influence response to a series of drugs used to treat childhood leukemia and breast cancer.
Dr. Weinshilboum's research has been continuously funded for decades by the National Institutes of Health and other Foundation funding mechanisms.
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Ming-Fen Ho, Cheng Zhang,Irene Moon, Mustafa Tuncturk, Brandon J. Coombes, Joanna Biernacka, Michelle Skime, Tyler S. Oesterle, Victor M. Karpyak, Hu Li,Richard Weinshilboum
Translational Psychiatryno. 1 (2024): 1-13
Ming-Fen Ho, Cheng Zhang,Brandon Coombes, Joanna Biernacka, Irene Moon, Michelle Skime, Paul Croarkin,Tyler Oesterle,Victor Karpyak, Hu Li,Richard Weinshilboum
NEUROPSYCHOPHARMACOLOGY (2023): 455-456
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Cynthia X. Ma,Araba A. Adjei, Oreste E. Salavaggione, Josefa Coronel, Linda Pelleymounter,Liewei Wang,Bruce W. Eckloff,Daniel Schaid,Eric D. Wieben,Alex A. Adjei,Richard M. Weinshilboum
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Liewei Wang,Katarzyna A. Ellsworth,Irene Moon,Linda L. Pelleymounter,Bruce W. Eckloff,Yvette N. Martin,Brooke L. Fridley, Gregory D. Jenkins,Anthony Batzler,Vera J. Suman, Saranya Ravi,J. Michael Dixon,
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Yuan Ji,Janet Olson, Jianping Zhang,Michelle Hildebrandt,Liewei Wang,James Ingle, Zachary Fredericksen,Thomas Sellers,William Miller,J. Michael Dixon,Hiltrud Brauch, Michel Eichelbaum,
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