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Dr. Rappuoli introduced several novel scientific concepts, the names of which have become well known. Examples are the concept that bacterial toxins can be detoxified by manipulation of their genes (genetic detoxification, 1987), the concept that microbes are better studied in the context of the cells they interact with instead of artificial laboratory conditions (cellular microbiology, 1996), the use of genomes to develop new vaccines (reverse vaccinology, 2000), the observation that the genome of a species (pangenome, 2005) is larger than the genome of an organism of the same species. Several molecules he worked with became part of licensed vaccines. He characterized a molecule, CRM197, that today is the most widely used carrier for vaccines against H. influenzae, N. meningitidis and pneumococcus vaccines, and is used to vaccinate most children around the globe. He then developed a vaccine against pertussis by engineering B. pertussis to produce a non-toxic pertussis toxin antigen. This was the first rationally designed molecule approved for human use. Later, he developed the first conjugate vaccine against meningococcus C that eliminated the disease in the UK in 2000. In 1997, he obtained regulatory approval for MF59, the first vaccine adjuvant approved for human use after the approval of aluminium salts in the 1920s. MF59 is now being used in many other experimental vaccines, the most advanced of which is a vaccine against pandemic influenza. He pioneered the use of genomic information for vaccine development (reverse vaccinology). Its application led to the licensure of the first meningococcus B vaccine in Europe in 2013 and in the USA in 2015. The vaccine was introduced for routine immunization for all new-borns in the UK since September 2015, and the first report showed an effectiveness of 83%.
研究兴趣
论文共 1397 篇作者统计合作学者相似作者
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Emanuele Roscioli, Vittoria Zucconi Galli Fonseca, Soraya Soledad Bosch,Ida Paciello,Giuseppe Maccari, Giampiero Batani,Samuele Stazzoni, Giulia Cardinali,Giusy Tiseo,Cesira Giordano,Yuwei Shen, Laura Capoccia,
biorxiv(2024)
Ida Paciello,Giulio Pierleoni,Elisa Pantano,Giada Antonelli,Piero Pileri,Giuseppe Maccari,Dario Cardamone, Giulia Realini, Federica Perrone, Martin Mayora Neto,Simone Pozzessere,Massimiliano Fabbiani,
biorxiv(2024)
Nicole V Johnson, Steven C Wall, Kevin J Kramer, Clinton M Holt,Sivakumar Periasamy,Simone Richardson,Naveenchandra Suryadevara,Emanuele Andreano,Ida Paciello,Giulio Pierleoni,Giulia Piccini, Ying Huang,
bioRxiv : the preprint server for biology (2024)
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 3 (2024): e2314730121-e2314730121
Giampiero Batani, Giacomo Vezzani, Sabrina Lashchuk,Abdelmounaaim Allaoui,Dario Cardamone,Maria Michelina Raso,Elena Boero, Emanuele Roscioli, Matteo Ridelfi,Gianmarco Gasperini,Mariagrazia Pizza,Omar Rossi,
Frontiers in Immunology (2024)
Scientific Reportsno. 1 (2024): 1-12
Rino Rappuoli, Simone Pecetta
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature (2023)
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