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个人简介
My main personal research interest is in innate and adaptive immune regulation during health and in disease, which I have studied for the last twenty-five years. I have investigated this in autoimmune thyroiditis (1992-98) and CD8+ T cell homeostasis, focusing on its role in graft rejection (1999-2004) with the support of the American Heart Association. Here my contributions to science included evaluation of the regulation of allo- and auto-reactive T cells. There is a clinical need for achieving tolerance during autoimmunity and allotransplantation. I studied the role of incomplete antigen stimulation in producing tolerized and regulatory T cells. I utilized two novel in vivo systems to achieve this:1) I first defined the role of non-professional antigen presenting cells in regulating antigen-specific autoimmune thryroiditis, and 2) engineered soluble MHC Class I tetramers and first described molecular (including co-receptor dependence and CD8+ Foxp3+ expression) and cellular mechanisms (intra-antigen specificity regulation of CD8+ T cells) of dynamically “tuned” cytotoxic CD8+ T cell responses in models of skin transplantation and peripheral tolerance in autoimmunity.
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JOURNAL OF TRAUMA AND ACUTE CARE SURGERYno. 4 (2024): 548-556
Parth Chansoria, Ameya Chaudhari, Emma L Etter,Emily E Bonacquisti, Mairead K Heavey, Jiayan Le,Murali Kannan Maruthamuthu, Caden C Kussatz,John Blackwell,Natalie E Jasiewicz, Rani S Sellers,Robert Maile,
Nature communicationsno. 1 (2024): 4720-4720
Surgery (2024)
Frontiers in immunology (2023): 1188830
Journal of leukocyte biologyno. 5 (2023): 384-386
The journal of trauma and acute care surgeryno. 5 (2022): 702-711
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