Robert Bonomo
教授
Department of Pharmacology
School of Medicine, Case Western Reserve University;Cleveland Center for Membrane & Structural Biology, School of Medicine, Case Western Reserve University;Department of Molecular Biology and Microbiology, School of Medicine, Case Western Reserve University;Department of Medicine, School of Medicine, Case Western Reserve University
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基本信息
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个人简介
Among the major problems faced in medicine, resistance to antibiotics is regarded as a singular challenge. The primary focus of our laboratory is to understand the genetic and amino acid sequence determinants of the enzymes that inactivate ß-lactams, the ß-lactamases. Our current work is directed at solving three main problems:
how ß-lactamase inhibitors inactivate -lactamases;
how ß-lactamases hydrolyze advanced generation cephalosporins; and
how mutations impact upon ß-lactamase expression. We are also interested in how penicillin interacts with penicillin resistant PBPs and the molecular epidemiology of extended spectrum ß-lactamases (ESBLs).
研究兴趣
论文共 797 篇作者统计合作学者相似作者
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Alina Iovleva, Christi L McElheny, Erin L Fowler,Eric Cober,Erica S Herc,Cesar A Arias,Carol Hill, Keri Baum,Vance G Fowler,Henry F Chambers,Kerryl E Greenwood-Quaintance,Robin Patel,
Antimicrobial agents and chemotherapyno. 3 (2024): e0125823-e0125823
Antimicrobial agents and chemotherapypp.e0172023-e0172023, (2024)
Yuanyuan Jiao, Jun Yan,Dhruvitkumar S Sutaria,Peggy Lu,Michael Vicchiarelli,Zeferino Reyna, Juan Ruiz-Delgado,Elizabeth Burk,Eugene Moon,Nirav R Shah,Brad Spellberg,Robert A Bonomo,
Zachary L. Klamer,Cynthia M. June,Zdzislaw Wawrzak,Magdalena A. Taracila, Joshua A. Grey, Alyssa M. I. Benn, Christopher P. Russell,Robert A. Bonomo,Rachel A. Powers,David A. Leonard,Agnieszka Szarecka
Journal of Molecular Biologypp.168603-168603, (2024)
Yu Zhu,Jing Gu, Zhuoran Zhao,A W Edith Chan,Maria F Mojica,Andrea M Hujer,Robert A Bonomo,Shozeb Haider
Journal of chemical information and modelingno. 9 (2024): 3706-3717
ACS INFECTIOUS DISEASES (2024)
CLINICAL INFECTIOUS DISEASES (2024)
Khalid M Dousa,Eunjeong Shin, Sebastian G Kurz,Mark Plummer,Mary Nantongo, Christopher R Bethel,Magdalena A Taracila, David C Nguyen,Barry N Kreiswith, Charles L Daley,Kenneth E Remy, Steven M Holland,
mBiono. 6 (2024): e0060924-e0060924
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