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个人简介
My lab studies the mechanisms underlying chronic airway diseases including asthma, cystic fibrosis and COPD and how ion channel dysfunction contributes to these diseases. We also develop novel therapies for treating these diseases and closely partner with industry in this regard. Additionally, we are funded by the NIH/FDA to understand the impact of new and emerging tobacco products including e-cigarettes, hookah and little cigars on innate defense in the lung. For example, we have identified SPLUNC1 as a negative regulator of ENaC that is dysfunctional in cystic fibrosis airways, leading to airways dehydration and a failure of innate defense. We have since designed novel SPLUNC1-derived peptides that remain functional in cystic fibrosis lungs and are moving towards getting these peptides into the clinic to treat cystic fibrosis patients through an industry collaboration.
研究兴趣
论文共 262 篇作者统计合作学者相似作者
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Milica Vukmirovic,Kambez H Benam, Jason J Rose,Scott Turner,Chelsea M Magin,David Lagares, Alan H Cohen, Naftali Kaminski,Jeremy A Hirota,Toby M Maher,Melanie Konigshoff,Rama K Mallampalli,
Annals of the American Thoracic Societyno. 1 (2024): 1-11
Tabata Apablaza, Marisol Barros-Poblete,Livia Delpiano,Sandra Villanueva,Anita Guequen, Barbara Tapia-Balladares,Iram J Haq, Felipe Tribinos, Sebastian Hernandez-Rivas,Bernard Verdon, Matthew GS Biggart, Yenniffer Sanchez,
crossref(2024)
Saira Ahmad, Joe A Wrennall, Alexandra S Goriounova, Malika Sekhri, Jason A Iskarpatyoti, Arunava Ghosh, Sabri H Abdelwahab, Alexis Voeller, Mani Rai,Rahul Y Mahida, Krzysztof Krajewski, Diane M Ignar,
American journal of respiratory and critical care medicineno. 6 (2024): 703-715
Journal of applied toxicology : JATno. 6 (2023): 862-873
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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Journal of Cystic Fibrosis (2023): S12-S12
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2023)
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Journal of Cystic Fibrosis (2023): S2-S2
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