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The main research focus of my lab is to identify processes affecting the development and mineralization of dental enamel in the context of calcium and redox homeostasis, a process that also involves mithchondrial and ER calcium signaling. My research combines molecular biology, physiology, confocal and electron microscopy, genetics and morphology to identify key growth processes and pathways focusing largely on the intracellular environment of enamel cells.
An important mechanism under investigation relates to the modulation of calcium transport by the enamel cells, called ameloblasts. Calcium is critical for the development of enamel, but how calcium enters the enamel cells and how is then moved into the extracellular compartment where crystals grow remains poorly understood. The main pathway investigated in my lab is the calcium release activated calcium (CRAC) channels. This pathway is activated upon loss of calcium from the endoplasmic reticulum lumen. CRAC channels are formed by the ER-membrane bound STIM1 protein, and the plasma membrane, the pore subunit, ORAI1 protein. Activation of CRAC channels results in a sustained influx of calcium into the cell. This calcium elevation also has a role in signaling, and in enamel cells in vitro, modulates the expression of enamel genes. Mutations in STIM1 or ORAI1 genes result in severe combined immune deficiency, ectodermal dysplasia and amelogenesis imperfecta. To investigate the role/s of STIM1 and ORAI1 we have analyzed the enamel phenotype and the ameloblasts of CRAC channel-deficient mice.
In ameloblasts cells, the enamel forming cells, CRAC channels are important players in mitochondrial function and cell redox, processes that are virtually unknown in enamel.
I am also interested in mechanism of facial growth. In particular, in the processes mediating the growth of the maxillary complex, using animal models and the hominin fossil record to better understand constraints and plasticity of rostral form. Our goal is to assess key growth determinants in the evolution of the facial complex.
The main research focus of my lab is to identify processes affecting the development and mineralization of dental enamel in the context of calcium and redox homeostasis, a process that also involves mithchondrial and ER calcium signaling. My research combines molecular biology, physiology, confocal and electron microscopy, genetics and morphology to identify key growth processes and pathways focusing largely on the intracellular environment of enamel cells.
An important mechanism under investigation relates to the modulation of calcium transport by the enamel cells, called ameloblasts. Calcium is critical for the development of enamel, but how calcium enters the enamel cells and how is then moved into the extracellular compartment where crystals grow remains poorly understood. The main pathway investigated in my lab is the calcium release activated calcium (CRAC) channels. This pathway is activated upon loss of calcium from the endoplasmic reticulum lumen. CRAC channels are formed by the ER-membrane bound STIM1 protein, and the plasma membrane, the pore subunit, ORAI1 protein. Activation of CRAC channels results in a sustained influx of calcium into the cell. This calcium elevation also has a role in signaling, and in enamel cells in vitro, modulates the expression of enamel genes. Mutations in STIM1 or ORAI1 genes result in severe combined immune deficiency, ectodermal dysplasia and amelogenesis imperfecta. To investigate the role/s of STIM1 and ORAI1 we have analyzed the enamel phenotype and the ameloblasts of CRAC channel-deficient mice.
In ameloblasts cells, the enamel forming cells, CRAC channels are important players in mitochondrial function and cell redox, processes that are virtually unknown in enamel.
I am also interested in mechanism of facial growth. In particular, in the processes mediating the growth of the maxillary complex, using animal models and the hominin fossil record to better understand constraints and plasticity of rostral form. Our goal is to assess key growth determinants in the evolution of the facial complex.
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The Journal of general physiologyno. 1 (2024)
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Ga-Yeon Son, Anna Zou,Amanda Wahl, Kai Ting Huang,Manikandan Vinu, Saruul Zorgit,Fang Zhou,Larry Wagner,Youssef Idaghdour,David I Yule,Stefan Feske,Rodrigo S Lacruz
bioRxiv : the preprint server for biology (2024)
Yin-Hu Wang, Wenyi Li, Maxwell McDermott,Ga-Yeon Son,George Maiti,Fang Zhou, Anthony Tao, Dimitrius Raphael,Andre L Moreira, Boheng Shen,Martin Vaeth,Bettina Nadorp,
bioRxiv : the preprint server for biology (2024)
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AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGYno. 2 (2023): 352-369
AMERICAN JOURNAL OF BIOLOGICAL ANTHROPOLOGY (2023): 153-153
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JOURNAL OF GENERAL PHYSIOLOGYno. 1 (2023)
Caterina Vianello,Federica Dal Bello,Sang Hun Shin, Sara Schiavon,Camilla Bean, Ana Paula Magalhães Rebelo,Tomáš Knedlík, Emad Norouzi Esfahani,Veronica Costiniti,Rodrigo S. Lacruz,Giuseppina Covello,Fabio Munari,
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