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My lab is interested in elucidating the cellular and molecular mechanisms underlying learning and memory in the mammalian brain. Long-term potentiation (LTP), a phenomenon in which brief repetitive activity causes a long lasting (many weeks) enhancement in the strength of synaptic transmission, is generally accepted to be a key cellular substrate for learning and memory. My lab uses a combination of electrophysiological and molecular techniques to elucidate the molecular basis of LTP. We have found that LTP involves the rapid activity-dependent trafficking of glutamate receptors to the synapse. This trafficking requires the interaction of two families of synaptic proteins. One family is a novel group of proteins that, we discovered which bind to glutamate receptors and act as auxiliary subunits. These proteins are not only essential for the trafficking of the glutamate receptors, but also control the gating of the receptor channel. The other family is comprised of a family of scaffolding proteins that bind to the auxiliary subunits and thereby anchor the receptors at the synapse. Much of the current work in the lab is focused on how activity controls this receptor trafficking and how the increase in synaptic strength during LTP is stabilized and maintained.
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论文共 250 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2023)
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NEURONno. 15 (2023): 2280-2281
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Michael A. Bemben, Mauricio Sandoval,Aliza A. Le,Sehoon Won, Vann Chau,Julie C. Lauterborn,Salvatore Incontro,Kathy H. Li,Alma L. Burlingame,Katherine W. Roche,Christine M. Gall,Roger A. Nicoll,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Michael A Bemben, Matthew Sandoval,Aliza A Le,Sehoon Won, Vivian N Chau,Julie C Lauterborn,Salvatore Incontro,Kathy H Li,Alma L Burlingame,Katherine W Roche,Christine M Gall,Roger A Nicoll,
bioRxiv : the preprint server for biology (2023)
Physiological reviews (2023)
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PHYSIOLOGICAL REVIEWSno. 4 (2023): 2877-2925
Anagh Sinha Ravi,Menglong Zeng,Xudong Chen, Gerardo Sandoval,Javier Diaz-Alonso,Mingjie Zhang,Roger A. Nicoll
Cell Reportsno. 2 (2022): 111483-111483
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