Ronald J. Weigel
教授
Department of Surgery
Carver College of Medicine, University of Iowa;Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa;Department of Biochemistry and Molecular Biology, Carver College of Medicine, University of Iowa;Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa
关注
立即认领
分享
关注
立即认领
分享
基本信息
浏览量:4
职业迁徙
个人简介
The Weigel laboratory has had a long-standing interest in determining mechanisms of hormone response in breast cancer. Our work has identified transcriptional mechanisms that regulate the expression of estrogen receptor- alpha in breast carcinomas. Other areas of investigation have sought to identify genes that are related to hormone response and additional mechanisms of gene regulation that are responsive to estrogen. Current Projects Regulation of ER by AP2 . We identified the AP2? transcription factor as a key regulator of hormone response in breast cancer. We are now examining mechanisms of gene regulation that involve this transcription factor. Chromatin Effects Altering AP2 Activity. We have shown that epigenetic chromatin alterations can influence activity of AP2 at certain promoters. The mechanism appears to involve altered binding of AP2 mediated through chromatin structure. Studies to determine how chromatin structure alters AP2 activity are being pursued. Interaction of AP2 and p53. We demonstrated a direct interaction between AP2 factors and the p53 tumor suppressor. The interaction of p53 and AP2 has functional effects on these two factors that appear to alter hormone response in breast cancer and cell growth in other cancer types. We are investigating the details of this interaction and the functional effects on gene regulation and cell physiology.
研究兴趣
论文共 223 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
SURGERYno. 3 (2024): 574-578
Molecular and cellular biologyno. 12 (2023): 650-663
Jeffrey R. White,Dakota T. Thompson,Kelsey E. Koch, Boris S. Kiriazov,Anna C. Beck,Dana M. van der Heide, Benjamin G. Grimm,Mikhail V. Kulak,Ronald J. Weigel
crossref(2023)
Camilla Emma Marie Koczara,Anna C. Beck,Jerrod N. Keith,Sonia L. Sugg,Ingrid Marie Lizarraga,Ronald J. Weigel
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONSno. 5 (2023): S11-S12
引用0浏览0引用
0
0
Nicholas Borcherding, David Kusner,Ryan Kolb, Qing Xie, Wei Li, Fang Yuan,Gabriel Velez,Ryan Askeland,Ronald J. Weigel,Weizhou Zhang
crossref(2023)
Jeffrey R. White,Dakota T. Thompson,Kelsey E. Koch, Boris S. Kiriazov,Anna C. Beck,Dana M. van der Heide, Benjamin G. Grimm,Mikhail V. Kulak,Ronald J. Weigel
crossref(2023)
American journal of surgeryno. 3 (2023): 308-309
Mohammed O Suraju, Kyle Freischlag, Denise Jacob,Dakota Thompson, Andrew Mckeen,Catherine Tran,Scott K Sherman,Paolo Goffredo,Ronald J Weigel,Imran Hassan
Surgeryno. 3 (2023): 735-742
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn