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Structure and Action of Molecular Machines
In cells there are hundreds of macromolecular assemblies. They may be composed of only a few or perhaps scores of proteins and are the functional units - the molecular machines - of the cell. We use cryo-electron microscopy and image analysis to study the structure and mechanism of action of several of these molecular machines. The three-dimensional maps we calculate from electron images of the assemblies are used together with the x-ray structures of the individual components to build models of the working machines and to understand their molecular mechanisms. We have ongoing research projects on the following assemblies: actomyosin, kinesin-microtubules, MAPs-microtubles, VCP/p97 and dynein AAA ATPases, various membrane channels and transporters, bacterial toxins.
研究兴趣
论文共 78 篇作者统计合作学者相似作者
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Nature Cell Biologyno. 7 (2022): 1088-1098
biorxiv(2019)
Developmental cellno. 5 (2019): 711-730.e8
mag(2013)
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