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职业迁徙
个人简介
During the course of my training as a physician, I was driven both by the art and the science of medicine- especially in the workings of the heart and circulation. More than thirty years later I am still grateful for the opportunities to decipher how the cardiovascular system works at a cellular and molecular level and how manipulating those cellular systems can either lead to blood vessel diseases or new treatment approaches.
Research Summary
My laboratory has helped to further our understanding of how blood vessels are regulated and how those systems breakdown in blood vessel diseases- including high blood pressure.
In hypertension, a failure of blood vessels to relax properly in response to hormones is one of the most important mechanisms leading to the development of hypertension. We discovered the molecular mechanism underlying that defect and identified the protein responsible (J Clin Invest.1997;99:2087-2093).
We now know that insulin has important effects on blood vessels- beyond its effects on regulation of glucose. We were the first to demonstrate how insulin caused blood vessel relaxation and that the ability of insulin to regulate blood vessels was impaired in diabetes, hypertension and with obesity (Lancet 1993; 342:707-709). These studies have been important in our understanding of the linkage between hypertension, diabetes and obesity.
Unraveling the cardiovascular effects of estrogen has been and remains an important question. On one hand, the lower rate of heart disease in women has in part been attributed to estrogen. However, post-menopausal estrogen replacement either does not protect or increases risk of cardiovascular disease. Studies from our laboratory have delineated the cellular basis for these two sided effects of estrogen and how an imbalance in those estrogen-driven systems can lead to high blood pressure and high cholesterol levels in women- two of the most important causes of heart disease and stroke.
In addition to my biomedical research program, I continue a clinical research program. Recent studies have focused on the development and determination of the effectiveness of novel approaches to manage hypertension and other atherosclerotic risk factors in the primary care setting.
Research Summary
My laboratory has helped to further our understanding of how blood vessels are regulated and how those systems breakdown in blood vessel diseases- including high blood pressure.
In hypertension, a failure of blood vessels to relax properly in response to hormones is one of the most important mechanisms leading to the development of hypertension. We discovered the molecular mechanism underlying that defect and identified the protein responsible (J Clin Invest.1997;99:2087-2093).
We now know that insulin has important effects on blood vessels- beyond its effects on regulation of glucose. We were the first to demonstrate how insulin caused blood vessel relaxation and that the ability of insulin to regulate blood vessels was impaired in diabetes, hypertension and with obesity (Lancet 1993; 342:707-709). These studies have been important in our understanding of the linkage between hypertension, diabetes and obesity.
Unraveling the cardiovascular effects of estrogen has been and remains an important question. On one hand, the lower rate of heart disease in women has in part been attributed to estrogen. However, post-menopausal estrogen replacement either does not protect or increases risk of cardiovascular disease. Studies from our laboratory have delineated the cellular basis for these two sided effects of estrogen and how an imbalance in those estrogen-driven systems can lead to high blood pressure and high cholesterol levels in women- two of the most important causes of heart disease and stroke.
In addition to my biomedical research program, I continue a clinical research program. Recent studies have focused on the development and determination of the effectiveness of novel approaches to manage hypertension and other atherosclerotic risk factors in the primary care setting.
研究兴趣
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The Canadian journal of cardiologyno. 12 (2023): 1808-1815
The Canadian journal of cardiologyno. 5 (2021): 679-682
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