基本信息
浏览量:0
职业迁徙
个人简介
Research Interests
Gastrulation is the first major morphogenetic event in animal development, which establishes the basic body plan of the organism. We study the cellular basis and the molecular control of gastrulation processes such as cell migration, cell rearrangement, and tissue boundary formation, using the Xenopus embryo as a model system. Molecularly, we focus on the role of cadherin-mediated adhesion, Eph receptor/ephrin ligand signalling, and non-canonical Wnt signalling in boundary formation and cell rearrangement, and on PDGF- and non-canonical Wnt signalling in cell migration. We also explore the mechanical properties of gastrula tissues, which determine the forces generated in the embryo, embryo structure, and the rate of tissue shape changes. For example, important mechanical parameters are tissue surface tension and tissue viscosity, and we developed methods to measure these in the Xenopus embryo, to see how they are correlated with gastrulation movements and controlled by molecular mechanisms such as Eph signalling. Altogether, our studies shed light not only on the fundamental process of gastrulation, but help to clarify basic general processes such as boundary formation and cell movement.
Gastrulation is the first major morphogenetic event in animal development, which establishes the basic body plan of the organism. We study the cellular basis and the molecular control of gastrulation processes such as cell migration, cell rearrangement, and tissue boundary formation, using the Xenopus embryo as a model system. Molecularly, we focus on the role of cadherin-mediated adhesion, Eph receptor/ephrin ligand signalling, and non-canonical Wnt signalling in boundary formation and cell rearrangement, and on PDGF- and non-canonical Wnt signalling in cell migration. We also explore the mechanical properties of gastrula tissues, which determine the forces generated in the embryo, embryo structure, and the rate of tissue shape changes. For example, important mechanical parameters are tissue surface tension and tissue viscosity, and we developed methods to measure these in the Xenopus embryo, to see how they are correlated with gastrulation movements and controlled by molecular mechanisms such as Eph signalling. Altogether, our studies shed light not only on the fundamental process of gastrulation, but help to clarify basic general processes such as boundary formation and cell movement.
研究兴趣
论文共 76 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Developmental Cellno. 1 (2024): 141-155.e6
PLOS ONEno. 2 (2024)
The International journal of developmental biologyno. 3 (2023): 79-90
加载更多
作者统计
#Papers: 81
#Citation: 3492
H-Index: 34
G-Index: 58
Sociability: 5
Diversity: 0
Activity: 0
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn