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In a traditionally adjacent field of study, RNA represents another biopolymer that is central to all known life. While the building blocks of RNA are canonically limited to four bases, post-transcriptional modifications (PTMs) can dramatically expand the chemical diversity of RNA, with >100 PTMs having been identified (Machnicka et al., 2013; Nachtergaele and He, 2016; Frye et al., 2018). It is therefore not surprising that the cellular role for RNA is more complex than that of a simple messenger. For instance, RNAs function as scaffolds, molecular decoys, enzymes, and network regulators across the nucleus and cytosol (Cech and Steitz, 2014; Sharp, 2009; Wang and Chang, 2011). With the exception of a few monosaccharide-based tRNA modifications (Kasai et al., 1976; Okada et al., 1977), there has been so far no evidence of a direct linkage between RNA and glycans in nature.
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Glycobiologyno. 1 (2024)
Petar Hristov,Ryan A. Flynn
NATURE BIOTECHNOLOGYno. 4 (2024): 574-575
Rong Zheng, Mikayla Dunlap,Georg O.M. Bobkov,Carlos Gonzalez-Figueroa, Khushali J. Patel,Jingyi Lyu,Samuel E. Harvey,Tracey W. Chan,Giovanni Quinones-Valdez,Mudra Choudhury, Charlotte A. Le Roux, Mason D. Bartels,
Molecular Cellno. 11 (2024): 2087-2103.e8
GLYCOBIOLOGY (2024)
bioRxiv the preprint server for biology (2024)
Cell Chemical Biology (2024)
Annual review of genomics and human geneticsno. 1 (2023): 85-107
Molecular Cellno. 10 (2023): 1623-1639.e8
biorxiv(2023)
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