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My research interests centre on the application and development of physical and chemical approaches to study biological phenomena at the nano-scale.
We use a combination of experimental and computational techniques, including microscopy, optics, nano-fabrication, spatial statistics, and image processing. We are particularly interested in super-resolution microscopy techniques, which are optical techniques that allow us to monitor the spatial organisation of single molecules and molecular assemblies, even in complex and crowded environments. We aim to develop the technology further in order to achieve fast, cell-compatible, super-resolution imaging of bio-molecules in living cells.
Specifically, we coupled these technologies to study biological processes in T-cells, which are white blood cells that scan our body for molecular signals of 'danger' activating an immune response when they recognise one. We want to learn how T-cells come to a decision of activating, which mechanisms are in place to prevent aberrant activation, and whether the cell membrane plays a role in modulating these responses. We are also interested in optimising current nanomaterials, designed to elicit an immune response, by characterising their interaction with T-cells.
We use a combination of experimental and computational techniques, including microscopy, optics, nano-fabrication, spatial statistics, and image processing. We are particularly interested in super-resolution microscopy techniques, which are optical techniques that allow us to monitor the spatial organisation of single molecules and molecular assemblies, even in complex and crowded environments. We aim to develop the technology further in order to achieve fast, cell-compatible, super-resolution imaging of bio-molecules in living cells.
Specifically, we coupled these technologies to study biological processes in T-cells, which are white blood cells that scan our body for molecular signals of 'danger' activating an immune response when they recognise one. We want to learn how T-cells come to a decision of activating, which mechanisms are in place to prevent aberrant activation, and whether the cell membrane plays a role in modulating these responses. We are also interested in optimising current nanomaterials, designed to elicit an immune response, by characterising their interaction with T-cells.
研究兴趣
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OPEN BIOLOGYno. 5 (2023): 220377-220377
Frontiers in Photonics (2022)
Elena Tomas Bort, Megan Joseph,Qiaoying Wang,Edward Carter,Nicolas Roth,Jessica Gibson, Ariana Samadi,Hemant Kocher,Sabrina Simoncelli,Peter J McCormick,Richard Philip Grose
biorxiv(2022)
Nature Communicationsno. 1 (2020): 1493
biorxiv(2019)
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