基本信息
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个人简介
My laboratory has a primary research focus on the studying the role of tumor microenvironment in the pathogenesis of epithelial ovarian cancer. We are particularly interested in evaluating the mechanisms thorough which stromal cell and ovarian cancer interact in the omental tumor microenvironment. My laboratory’s ongoing research projects include the use of next generation RNAseq to characterize non-coding RNAs and mRNAs delivered by cancer associated adipocyte (CAA), cancer associated fibroblast (CAF) and ovarian cancer cell derived exosomes and microvesicles; the use of transcriptome profiling, microdissection techniques, and systems biology approach to identify pathway networks that are activated in different cell types within the ovarian cancer microenvironment; the developing of 3D real-time co-culture models to evaluate the effect of various stromal cells on ovarian cancer cell growth, and invasion and motility potential, and the effect of ovarian cancer cells on angiogenesis; and the study of the impact of physical properties such as the rigidity of the extracellular matrix on ovarian cancer cell motility and invasion potential.
My Laboratory is also interested in identifying prognostic or predictive markers for ovarian cancer through comparative genomic hybridization (CGH) and transcriptome array analyses. We are particularly interested in functionally characterizing candidates that may be used as therapeutic targets in ovarian cancer treatment.
Research Interests
Identification of differentially expressed genes in human epithelial ovarian cancer
Genetic alterations in human borderline ovarian tumor
Genetic alterations in papillary seous carcinoma of the peritoneum
Role of signal transduction molecules in ovarian carcinogenesis
Molecular classification of epithelial ovarian tumors
Identification of markers for early detection of ovarian cancer
Stromal and epithelial cell interaction in ovarian cancer pathogenesis
Genetic polymorphisms and ovarian cancer risk
Application of nantotechnology in ovarian cancer detection and treatment
研究兴趣
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