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职业迁徙
个人简介
Research Overview–
We are studying the molecular basis of translational control of the Hepatitis C Virus and Coxsackievirus B3 RNAs. Translation of these viral RNAs are guided by Internal Ribosome Entry Site (IRES). Ribosome binding to the IRES element is mediated by a number of cellular proteins (trans-acting factors) and cis acting RNA elements. Such RNA-protein interactions that are critical for viral IRES function, form a major research area in the lab. In this context, the group has expanded its scope to investigate the mechanistic details of HCV and CVB3 replication, host-viral interactions and related aspects of immunity. Recently, studies have been extended to study the role of the cellular host factors viz. proteins, long non-coding RNAs and micro RNAs in virus induced cellular pathogenesis. In addition, our group has extended study to non-canonical modes of cellular RNA translation using tumor suppressor p53 RNA as a model system.
We are studying the molecular basis of translational control of the Hepatitis C Virus and Coxsackievirus B3 RNAs. Translation of these viral RNAs are guided by Internal Ribosome Entry Site (IRES). Ribosome binding to the IRES element is mediated by a number of cellular proteins (trans-acting factors) and cis acting RNA elements. Such RNA-protein interactions that are critical for viral IRES function, form a major research area in the lab. In this context, the group has expanded its scope to investigate the mechanistic details of HCV and CVB3 replication, host-viral interactions and related aspects of immunity. Recently, studies have been extended to study the role of the cellular host factors viz. proteins, long non-coding RNAs and micro RNAs in virus induced cellular pathogenesis. In addition, our group has extended study to non-canonical modes of cellular RNA translation using tumor suppressor p53 RNA as a model system.
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Priya Rani,Biju George, V Sabarishree, Somarghya Biswas, V Madhurya,Apala Pal,Raju S. Rajmani,Saumitra Das
Virusesno. 5 (2024)
MOLECULAR AND CELLULAR BIOLOGYno. 7 (2023): 335-353
WILEY INTERDISCIPLINARY REVIEWS-RNApp.e1826-e1826, (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Apala Pal,Debjit Khan,Sachin Kumar Tripathi, Pritam Kumar Ghosh,Sahana Ghosh,Subrata Patra,Arindam Maitra,Saumitra Das
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Rohan Narayan,Mansi Sharma,Rajesh Yadav,Abhijith Biji,Oyahida Khatun, Sumandeep Kaur,Aditi Kanojia, Christy Margrat Joy,Raju Rajmani,Pallavi Raj Sharma,Sharumathi Jeyasankar,Priya Rani,
Cell reports. Medicineno. 8 (2023): 101127-101127
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