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职业迁徙
个人简介
Our research focuses on regulation of the nuclear genome in mammals and model organisms. The long strands of nuclear DNA are associated with packaging proteins, called histones, into a structure known as chromatin, akin to the way thread is organized around a spool. We are particularly interested in changes in this chromatin structure via chemical modification of the histone proteins, and how attachment of certain chemical groups onto the histones leads to altered chromatin function. These targeted structural changes are conceptually like the unraveling of the thread to reach specific, buried sections. We are also fascinated by functional changes in chromatin, caused by these histone modifications, that persist through cell division from one cell into two daughter cells; these persistent, or epigenetic, changes are of particular interest because they are key to normal and abnormal growth: they occur during organismal development into multicellular tissues and organs, and are typically disrupted during abnormal reversal of tissue specialization and growth control as in cancer, as well as during aging of cells and individuals.
研究兴趣
论文共 366 篇作者统计合作学者相似作者
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Jae-Hyun Yang,Motoshi Hayano,Patrick T. Griffin,Joao A. Amorim,Michael S. Bonkowski, John K. Apostolides,Elias L. Salfati,Marco Blanchette, Elizabeth M. Munding,Mital Bhakta,Yap Ching Chew,Wei Guo,
Gabor Egervari, Desi C Alexander,Greg Donahue,Hua Huang, Connor Hogan,Mariel Mendoza,Benjamin A Garcia,Nancy M Bonini,Shelley L Berger
biorxiv(2024)
Daniel C. Xu,Hanna Sas-Nowosielska,Greg Donahue,Hua Huang, Naemeh Pourshafie,Charly R. Good,Shelley L. Berger
bioRxiv (Cold Spring Harbor Laboratory)no. 1 (2024): 1-19
Zhen Zhang,Amy E. Baxter,Diqiu Ren,Kunhua Qin,Zeyu Chen, Sierra M. Collins,Hua Huang, Chad A. Komar,Peter F. Bailer, Jared B. Parker,Gerd A. Blobel,Rahul M. Kohli,
Nature Biotechnologyno. 2 (2024): 305-315
Xue Hao,Bo Zhao, Martina Towers,Liping Liao, Edgar Luzete Monteiro, Xin Xu, Christina Freeman, Hongzhuang Peng,Hsin-Yao Tang, Aaron Havas,Andrew V. Kossenkov,Shelley L. Berger,
Nature Agingno. 2 (2024): 1-13
R Nativio,Y Lan,G Donahue,O Shcherbakova, N Barnett,KR Titus,H Chandrashekar, JE Phillips-Cremins,NM Bonini,SL Berger
biorxiv(2024)
Mingyang Zhou,Supuni Thalalla Gamage, Khoa A Tran,David Bartee,Xuepeng Wei, Boyu Yin,Shelley Berger,Jordan L Meier,Ronen Marmorstein
bioRxiv : the preprint server for biology (2024)
bioRxiv : the preprint server for biology (2024)
Allison Cote, Aoife O'Farrell, Ian Dardani, Margaret Dunagin,Chris Cote, Yihan Wan,Sareh Bayatpour, Heather L. Drexler, Katherine A. Alexander,Fei Chen, Asmamaw T. Wassie, Rohan Patel,
ELIFE (2024)
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