基本信息
浏览量:118
职业迁徙
个人简介
Chen’s interests have recently shifted to ABC transporters involved in the immune system and disease. Her work on two such transporters, P-glycoprotein and MRP1, has led to new insights into a mechanism by which some cancer cells mount resistance to chemotherapy. Discovered in the 1970s, P-glycoprotein recognizes an array of structurally related compounds and pumps them out of the cell. It plays a Jekyll-and-Hyde role in human health: When the cell in question is cancerous and the compounds are therapies targeting some aspect of the cell’s internal machinery, P-glycoprotein’s action reduces the effectiveness of chemotherapy. But, by doing essentially the same thing, P-glycoprotein also helps maintain the integrity of the blood–brain barrier by keeping certain types of molecules from entering the central nervous system.
研究兴趣
论文共 309 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Fangyu Liu,Anat Levit Kaplan,Jesper Levring,Jürgen Einsiedel,Stephanie Tiedt, Katharina Distler, Natalie S Omattage,Ivan S Kondratov,Yurii S Moroz, Harlan L Pietz, John J Irwin,Peter Gmeiner,
bioRxiv : the preprint server for biology (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 10 (2024): e2316675121-e2316675121
Proceedings of the National Academy of Sciences of the United States of Americano. 9 (2024): e2316673121-e2316673121
Ming-Hao Liu, Hai-Ming Liu,Li-Jian Gao,Tao Tian,Ang Li, Qing-Kai Wang,Xiong-Jing Jiang,Wei-Xian Yang,Yong-Jian Wu,Bo Xu,Jue Chen,Jin-Qing Yuan
The journal of vascular accesspp.11297298231154303, (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Natureno. 7961 (2023): E11-E11
Proceedings of the National Academy of Sciences of the United States of Americano. 11 (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn