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Cancer is characterised by changes in cellular signalling pathways that regulate growth, survival, differentiation and invasion. We are seeking to improve the treatment of ovarian and breast cancer by developing therapeutic strategies that target the oestrogen receptor (ER), erbB / HER and DNA repair pathways and their related signalling pathways more effectively. Individual cancers have differing degrees of dependency on these pathways and we are investigating the associations between cell signalling via these receptors and cell fate; specifically linkage between pathway activation and outcomes such as growth, apoptosis and migration. We are characterising relevant subgroups of cancers amenable to appropriate therapeutic interventions based on specific inhibitors i.e. moving towards more personalised patient / tumour treatment. As part of this we are evaluating new inhibitors in preclinical models. We are also seeking to improve the use of radiotherapy in breast cancer. One of the limitations to its effectiveness is the development of hypoxia in poorly vascularised regions of the tumour. To counteract this, strategies that target hypoxic regions are under investigation. Other metabolic pathways modified within cancer cells that might prove useful as targets are also being investigated.
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Wataru Sakai,Elizabeth M. Swisher,Céline Jacquemont, Kurapaty Venkatapoorna Chandramohan,Fergus J. Couch,Simon P. Langdon, Kaitlyn Wurz, Jake Higgins,Emily Villegas,Toshiyasu Taniguchi
crossref(2023)
Dana Faratian,Alexey Goltsov, Galina Lebedeva,Anatoly Sorokin, Stuart Moodie,Peter Mullen,Charlene Kay,In Hwa Um,Simon Langdon,Igor Goryanin,David J. Harrison
crossref(2023)
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Exploration of targeted anti-tumor therapyno. 1 (2022): 97-116
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