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My major research interests relate to the lung injury caused by mechanical ventilation: so called ventilator-induced lung injury (VILI). Specifically, my lab is working on (1) biotrauma: the molecular mechanisms by which injurious forms of mechanical ventilation can lead to release of mediators; (2) the mechanisms by which these mediators can affect distal organs (e.g. kidney, liver, etc.) and lead to multiple organ dysfunction syndrome (MODS); and (3) therapeutic approaches (ventilatory and non-ventilatory) to mitigate VILI and biotrauma. My laboratory works very closely with Dr. Zhang’s laboratory, and makes use of a number of model systems including in vitro, ex vivo cell and various animal models. As well, I have a major interest in clinical trials related to mechanical ventilation, acute lung injury (ALI), acute respiratory distress syndrome (ARDS), and COVID-19.
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Nickjaree Songsangvorn,Yonghao Xu,Cong Lu,Ori Rotstein,Laurent Brochard,Arthur S. Slutsky, Karen E. A. Burns,Haibo Zhang
Intensive Care Medicinepp.1-15, (2024)
Chel Hee Lee, Mohammad M. Banoei, Mariam Ansari,Matthew P. Cheng,Francois Lamontagne,Donald Griesdale, David E. Lasry,Koray Demir,Vinay Dhingra,Karen C. Tran,Terry Lee,Kevin Burns,
Critical Careno. 1 (2024): 1-16
American journal of respiratory and critical care medicineno. 6 (2023): 739-742
CRITICAL CARE MEDICINEno. 12 (2023): 1638-1649
American journal of respiratory and critical care medicineno. 1 (2023): 37-47
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