His research interests are mainly in the areas of big data, cloud computing, mobile computing, and distributed systems with over 500 papers published in major conferences and journals. He is the recipient of the 2019 IEEE TCBD Best Conference Paper Award, 2018 IEEE TCGCC Best Magazine Paper Award, 2017 IEEE Systems Journal Annual Best Paper Award, and other 6 Best Paper Awards from IEEE/ACM conferences. His work was also recognized by the 2016 Annual Best of Computing: Notable Books and Articles in Computing in ACM Computing Reviews. Prof. Guo was an IEEE ComSoc Distinguished Lecturer.