His research interests are mainly in edge AI, 6G, big data and machine learning, mobile computing, and distributed systems. Prof. Guo's research has been sponsored by RGC, NSFC, ITF, MOST, NRC, JSPS, MIC, JST, industry, etc. He published many papers in top venues with wide impact in these areas and was recognized as a Highly Cited Researcher (Clarivate Web of Science). He is the recipient of the 2020 Best Paper Award for IEEE Transactions on Computers, 2019 IEEE TCBD Best Conference Paper Award, 2018 IEEE TCGCC Best Magazine Paper Award, 2019 & 2017 IEEE Systems Journal Annual Best Paper Award, and other 8 Best Paper Awards from IEEE/ACM conferences. He also received the Faculty Award for Outstanding Achievement in Research and Scholarly Activities twice.
Prof. Guo served for IEEE Communications Society as a Distinguished Lecturer, Member of Board of Governors, Director of Membership Services, and Chair of Technical Committee of Space and Satellite Communications. He has also served for IEEE Computer Society on Fellow Evaluation Committee, Transactions Operations Committee, Steering Committee of IEEE Transactions on Cloud Computing, Editor-in-Chief Search Committee, etc. Prof. Guo has been named on editorial board of a number of prestigious international journals like IEEE Transactions on Computers, IEEE Transactions on Parallel and Distributed Systems, IEEE Transactions on Cloud Computing, IEEE Transactions on Emerging Topics in Computing, IEEE Transactions on Sustainable Computing, ACM Computing Surveys, IEEE Internet of Things Journal, etc. He has also served as chair of organizing and technical committees of numerous international conferences. Prof. Guo is a frequently invited expert for various national and international grant reviews. He is currently on RGC engineering panel.