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职业迁徙
个人简介
Our research concentrates on the molecular understanding of fundamental cellular processes. Firstly, we are interested in membrane homeostasis in eukaryotic cells and secondly we want to understand the molecular details of muscle contraction. Another focus is on the molecular understanding of the mechanism of action of bacterial toxin complexes.
Our overarching goal is to understand the mechanisms underlying these processes in the healthy and diseased organism in molecular detail. To achieve this, it is essential to elucidate the structure and thus the function of the involved proteins and protein complexes.
We perform structural analyses by single particle cryo-EM and X-ray crystallography, fluorescence-based assays and site-directed mutagenesis to determine the structures and functions of these complexes. For their biophysical characterization we employ isothermal titration calorimetry, ESI-MS, bio-layer interferometry, thermophoresis and CD spectroscopy.
Our overarching goal is to understand the mechanisms underlying these processes in the healthy and diseased organism in molecular detail. To achieve this, it is essential to elucidate the structure and thus the function of the involved proteins and protein complexes.
We perform structural analyses by single particle cryo-EM and X-ray crystallography, fluorescence-based assays and site-directed mutagenesis to determine the structures and functions of these complexes. For their biophysical characterization we employ isothermal titration calorimetry, ESI-MS, bio-layer interferometry, thermophoresis and CD spectroscopy.
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论文共 228 篇作者统计合作学者相似作者
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Nature Microbiologyno. 2 (2024): 390-404
Soumitra Polley,Tobias Raisch, Sabrina Ghetti, Marie Körner, Melina Terbeck,Frauke Gräter,Stefan Raunser,Camilo Aponte-Santamaría,Ingrid R. Vetter,Andrea Musacchio
Nature Structural & Molecular Biologypp.1-13, (2024)
Peter Njenga Ng`ang`a, Julian Folz, Svetlana Kucher,Daniel Roderer, Ying Xu, Oleg Sitsel, Alexander Belyy, Daniel Prumbaum,Ralf Kuehnemuth,Tufa E Assafa,Min Dong,Claus A.M. Seidel,
biorxiv(2024)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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NATURE COMMUNICATIONSno. 1 (2023): 8226-8226
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Natureno. 7988 (2023): 1-9
NATURE METHODSno. 6 (2023): 871-880
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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