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个人简介
Dr. Shoelson’s interests include developing new treatment strategies based on underlying pathophysiology and the pathophysiology of insulin resistance and diabetes. His laboratory identifies physiological and pathological mechanisms in metabolism with the potential for development of new therapeutics. Through a series of basic and clinical studies (TINSAL-T2D) his showed that salicylate, the world’s oldest anti-inflammatory drug, lowers blood sugar and lipids in patients with diabetes.
They have taken these discoveries back to the laboratory to understand molecular mechanisms and to expand the approach. Several new lines of investigation have spun off from TINSAL-T2D and studies of salicylate’s mechanism of action: 1) Based on the discovery that salicylate binds and activates AMPK, we subsequently found that AMPK activation is also required for salicylate’s anti-inflammatory effects through NF-kB inhibition.
研究兴趣
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Giulio R. Romeo,Yosuke Shikama,Maria E. Soares Martins Dos Santos, Sanjay Bhanot, Jongsoon Lee,Steven E. Shoelson
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