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An unsupervised network analysis showed that over-expression of digenomic proteins in hybrids is associated with elevated levels of proteostasis elements including chloroplast chaperones and protein complex assembly factors. We are exploring whether these proteostasis elements cause the increased levels of digenomic protein complexes. In contrast, inbreds display elevated levels of ERAD and UPR indicating they are experiencing proteostasis stress. Our focus, therefore, is on the relationship between proteostasis and heterosis.
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C J Crooks,J West,J R Morling,M Simmonds,I Juurlink,S Briggs, S Cruickshank, S Hammond-Pears,D Shaw,T R Card,A W Fogarty
Proceedings of the National Academy of Sciences of the United States of Americano. 48 (2023)
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CLINICAL MEDICINEno. 3 (2023): 201-205
Zhengyao Shao, Liangqiao Bian, Shyon K Ahmadi, Tyler J Daniel, Miguel A Belmonte,Jackson G Burns,Prashanth Kotla,Yang Bi,Zhouxin Shen,Shou-Ling Xu,Zhi-Yong Wang,Steven P Briggs,
bioRxiv : the preprint server for biology (2023)
Respiratory physiology & neurobiology (2023): 104098-104098
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Iain Au-Yong,Yutaro Higashi, Elisabetta Giannotti,Andrew Fogarty,Joanne R. Morling,Matthew Grainge, Andrea Race, Irene Juurlink,Mark Simmonds,Steve Briggs, Simon Cruickshank, Susan Hammond-Pears,
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01.05 - Clinical respiratory physiology, exercise and functional imaging (2022)
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