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Dr. Yuspa received his B.S. from Johns Hopkins University and his M.D. from the University of Maryland Medical School. He completed his internship and residency at the Hospital of the University of Pennsylvania and has been a senior investigator at the NCI since 1972. Among his honors are the Lila Gruber Award of the American Academy of Dermatology and the Clowes Award from the American Association for Cancer Research. Dr. Yuspa is author of more than 400 publications in the fields of carcinogenesis and epithelial differentiation.Dr. Yuspa has focused his research on understanding mechanisms of the pre-metastatic stages of cancer pathogenesis. Using the model of skin carcinogenesis, his work has delineated the biochemistry associated with oncogenic RAS induced benign squamous neoplasia and the multistep progression to squamous cell carcinoma. The findings reflect squamous cell cancer development in multiple internal lining epithelia and the interaction of cancer cells with the microenvironment.
As Co-Chief, Dr. Yuspa oversees a large interactive basic cancer research laboratory utilizing state-of-the- art approaches to understand cancer pathogenesis and progression in multiple target sites with the goal of translating discoveries into clinical advances.
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The Molecular Basis of Cancer (2008)
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